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isothiobarbamin

thiobarbituric acid derivative

Also Known As:

isothiobarbamine; isothiorbamin; 4(1H)-Pyrimidinone, 2-((2-(diethylamino)ethyl)thio)-6- hydroxy-5-(1-methylethyl)-, monohydrochloride

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Barbiturates: 1074
        Thiobarbiturates: 4
        isothiobarbamin: 3

Related Diseases

1.	Hypoxia (Hypoxemia) 04/01/1985 - "A study was made of the effects of isothiobarbamine and guthimine (10 and 50 mg/kg, respectively) on the content of cAMP and cGMP in the brain cortex (BC) and hippocamp under normal conditions and hypoxia. " 04/01/1985 - "Isothiobarbamine did not change the content of both cyclic nucleotides under normoxia, whereas under hypoxia it reduced the level of the cyclic nucleotides in the BC and raised it in the hippocamp. " 07/01/1988 - "Isothiobarbamin injected intravenously to cats in the phase of circulatory hypoxia 1-2 days after intracerebral hemorrhage improves the functional activity, blood supply, oxygen supply to the brain, prevents excessive accumulation of lactate in the brain tissue. "
2.	Cerebral Hemorrhage 07/01/1988 - "[Use of isothiobarbamin in the correction of disorders of the vital activities of the brain in intracerebral hemorrhage]." 12/01/1988 - "[Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]." 07/01/1988 - "Isothiobarbamin injected intravenously to cats in the phase of circulatory hypoxia 1-2 days after intracerebral hemorrhage improves the functional activity, blood supply, oxygen supply to the brain, prevents excessive accumulation of lactate in the brain tissue. " 12/01/1988 - "In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats."
3.	Brain Edema (Cerebral Edema) 12/01/1988 - "[Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]." 12/01/1988 - "In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats."

Related Drugs and Biologics

1.	Guanylthiourea
2.	Lactic Acid (Lactate)
3.	Oxygen (Dioxygen)
4.	Cyclic Nucleotides
5.	Glucose (Dextrose)
6.	Carbohydrates