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GB 52

thiorphan derivative enkephalinase inhibitor; no further info available 11/86

Also Known As:

GB-52

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfur Amino Acids: 221
    - Thiorphan: 64
      - GB 52: 1
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - N-substituted Glycines
      - Thiorphan: 64
        GB 52: 1
  - Sulfur Amino Acids: 221
    - Thiorphan: 64
      - GB 52: 1

Related Diseases

1.

08/01/1986 - "It was found that neither the nociceptive motor responses (Tr and Tmr) nor the subjective reports of pain (Tp and Tip), were significantly affected by GB 52. "
08/01/1986 - "The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans."
08/01/1986 - "The effects of intravenous administration of 2.5 mg/kg of GB 52, a highly potent derivative of the enkephalinase inhibitor, thiorphan, were studied on the threshold of both the nociceptive reflex (Tr) and sensation of pain (Tp) as well as on the thresholds of both recruitment of the maximal nociceptive reflex response (Tmr) and tolerable pain (Tip), elicited by electrical stimulation of the sural nerve in normal and relaxed volunteers. "

Related Drugs and Biologics

1.	Neprilysin (Neutral Endopeptidase)
2.	Thiorphan

Related Therapies and Procedures

1.	Intravenous Administration