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gonadotropin releasing hormone associated peptide

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56 amino acid sequence peptides given in first source for human & rat; joined to LHRH by 3 amino acid processing site

Also Known As:

GAP peptide; GnRH-associated peptide; LHRH prohormone GAP peptide; hGAP; rGAP

Networked: 11 relevant articles (0 outcomes, 3 trials/studies) for this Bio-Agent, Comments

Bio-Agent Context: Research Results

Experts

1.	Rhee, Man-Hee: 1 article (01/2010)
2.	Kyung, Jong-Soo: 1 article (01/2010)
3.	Kwak, Yi-Seong: 1 article (01/2010)
4.	Kim, Jong Soo: 1 article (01/2010)
5.	Cho, Jae Youl: 1 article (01/2010)
6.	Sohn, Eunwha: 1 article (07/2008)
7.	Rhee, Dong-Kwon: 1 article (07/2008)
8.	Pyo, Suhkneung: 1 article (07/2008)
9.	Park, Jong-Dae: 1 article (07/2008)
10.	Moon, Eun-Yi: 1 article (07/2008)

Related Diseases

1.	Experimental Melanoma 07/01/2008 - "This study examined the effects of red ginseng acidic polysaccharide (RGAP) on macrophage-mediated cytotoxicity towards murine melanoma B16 cells. " 11/01/2004 - "The present study demonstrates a synergistic antitumor effect of RGAP and paclitaxel in mice transplanted with sarcoma 180 and B16 melanoma. " 11/01/2004 - "When a combination of paclitaxel (10 mg/kg) and RGAP (100 mg/kg) was administered to C57BL/6 mice implanted with B16 melanoma, the tumor weight per mouse also decreased by 76.3 %, suggesting that RGAP may be used as an adjuvant in medicinal applications of paclitaxel. " Order ALL the reference details at left...
2.	Neoplasms (Cancer) 01/01/2010 - "It has been reported that red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng, displays immunostimulatory and anti-tumor activities. " 07/01/2008 - "RGAP alone had no effect on killing of tumor cells. " 07/01/2008 - "However, treatment of macrophages with a combination of RGAP and recombinant interferon-gamma (rIFN-gamma) enhanced killing of tumor cells. " 11/01/2004 - "The above results suggest that clinical trials of RGAP as an adjuvant in cancer chemotherapy of paclitaxel are highly feasible." 11/01/2004 - "When a combination of paclitaxel (10 mg/kg) and RGAP (100 mg/kg) was administered to C57BL/6 mice implanted with B16 melanoma, the tumor weight per mouse also decreased by 76.3 %, suggesting that RGAP may be used as an adjuvant in medicinal applications of paclitaxel. " Order ALL the reference details at left...
3.	Hyperprolactinemia 11/01/1992 - "CONCLUSIONS: No large deletions of the GnRH-associated peptide gene appear to be present in our patients with hyperprolactinemia. " 11/01/1992 - "DESIGN: Patients with hyperprolactinemia and controls were studied retrospectively for GnRH-associated peptide gene mutations. " 11/01/1992 - "Gonadotropin-releasing hormone-associated peptide gene sequences in women with hyperprolactinemia." 05/01/1987 - "Transient hyperprolactinemia observed in the current study might be attributable to a relative increase in GnRH to a GnRH-associated peptide (GAP), a constituent of GnRH prohormone and possessing an intrinsic effect of PRL suppression, by exogenously administered GnRH, causing overwhelming superiority of GnRH-mediated PRF. " 11/01/1992 - "OBJECTIVE: To determine if mutations in the structural gene for gonadotropin-releasing hormone (GnRH)-associated peptide are present in women with hyperprolactinemia. " Order ALL the reference details at left...
4.	Sarcoma 180 11/01/2004 - "The present study demonstrates a synergistic antitumor effect of RGAP and paclitaxel in mice transplanted with sarcoma 180 and B16 melanoma. " 11/01/2004 - "Combined treatment with paclitaxel (5 or 15 mg/kg) and RGAP (25 mg/kg) resulted in a 28.6 or 42.8 % increase in the life span of ICR mice bearing sarcoma 180 tumor cells, while no obvious effect was seen on sole paclitaxel treatment. " Order ALL the reference details at left...
5.	Protein Deficiency 01/01/1993 - "Effect of protein deficiency on luteinizing hormone releasing hormone (LHRH), gonadotropin releasing hormone associated peptide (GAP) and luteinizing hormone (LH) immunocytochemistry in the hypothalamus and pituitary gland of prepubertal ewes." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	Paclitaxel (Taxol)
3.	Prolactin
4.	Recombinant Interferon-gamma (Interferon gamma, Recombinant)
5.	Thyrotropin-Releasing Hormone (Protirelin)
6.	Luteinizing Hormone (Lutropin)
7.	Immunologic Factors (Immunomodulators)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration

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