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CL 277082
structure given in first source
Also Known As:
CL-277082; DDPMHU; N'-(2,4-difluororphenyl)-N-((4-(2,2-dimethylpropyl)phenyl)methyl)-N-heptylurea
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Phenylurea Compounds: 1
CL 277082: 2
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenylurea Compounds: 1
CL 277082: 2
Related Diseases
1.
Hypercholesterolemia
10/01/1992 - "
The induction of intestinal ACAT activity in diabetic rats, its modulation by insulin, and the hypocholesterolemic effects of insulin or CL-277082 treatment clearly indicate that ACAT activity plays a major role in the initiation of diabetes-associated hypercholesterolemia.
"
2.
Granuloma
05/02/1988 - "
Additionally, CL 277082 was shown to inhibit granuloma tissue ACAT activity by 45%, VLDL mass was decreased slightly, LDL mass increased 3.4-fold and HDL mass was similar in both the inhibitor-treated and control animals.
"
05/02/1988 - "
Influence of the acyl-CoA: cholesterol O-acyltransferase inhibitor, CL 277082, on cholesteryl ester accumulation in rabbit macrophage-rich granulomas and hepatic tissue.
"
05/02/1988 - "
The influence of the acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor, CL 277082, on macrophage cholesteryl ester accumulation in a rabbit carrageenan granuloma macrophage-foam cell model was studied.
"
Related Drugs and Biologics
1.
Insulin (Novolin)
2.
Cholesterol Esters (Cholesteryl Esters)
3.
Sterol O-Acyltransferase
4.
Carrageenan
5.
oxidized low density lipoprotein