nonactin

macrolide tetrolide antibiotic isolated from cycloheximide-producing species of Streptomyces; minor descriptor (75-86); on-line & INDEX MEDICUS search ANTIBIOTICS (75-86)

Also Known As:

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Akiyama, K: 2 articles (01/2001 - 07/2000)
2.	Mori, A: 2 articles (01/2001 - 07/2000)
3.	Okudaira, H: 2 articles (01/2001 - 07/2000)
4.	Aono, Harumi: 1 article (04/2017)
5.	Futamura, Yushi: 1 article (04/2017)
6.	Imoto, Masaya: 1 article (04/2017)
7.	Inoue, Hiroyuki: 1 article (04/2017)
8.	Kawada, Manabu: 1 article (04/2017)
9.	Kiga, Masaki: 1 article (04/2017)
10.	Osada, Hiroyuki: 1 article (04/2017)

Related Diseases

1.	Eosinophilia 01/01/2001 - "The effect of nonactin on the airway eosinophilia was investigated using murine asthma model. " 07/01/2000 - "Nonactin only suppressed IL-5 synthesis and was as effective against eosinophilia as cyclosporin A and dexa-methasone, which indicates that IL-5 is a reasonable therapeutic target in allergic disorders that are accompanied by eosinophilic inflammation." 07/01/2000 - "Nonactin suppressed IL-5 synthesis but not IL-2 or IL-4 synthesis, and it also significantly suppressed airway eosinophilia. " 01/01/2001 - "Nonactin suppressed IL-5 synthesis by human Th cells in a dose-dependent manner without affecting IL-2 or IL-4 synthesis, and still significantly suppressed murine airway eosinophilia induced by the antigen inhalation. "
2.	Inflammation (Inflammations) 07/01/2000 - "Nonactin only suppressed IL-5 synthesis and was as effective against eosinophilia as cyclosporin A and dexa-methasone, which indicates that IL-5 is a reasonable therapeutic target in allergic disorders that are accompanied by eosinophilic inflammation."
3.	Neoplasms (Cancer) 04/01/2017 - "Significant tumor regression was observed in the β-catenin mutant HCT 116 xenograft model, but not in the β-catenin wild type A375 xenograft model, in response to daily administration of nonactin in vivo. " 04/01/2017 - "Nonactin, as well as other mitochondrial uncouplers, induced apoptosis selectively in β-catenin mutated tumor cells. " 07/01/1999 - "Nonactin is a significant compound because of its inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 04/01/2017 - "Therefore, they undergo apoptosis in response to mitochondrial dysfunction following the addition of mitochondrial uncouplers, such as nonactin. "
5.	Lymphoma (Lymphomas) 06/01/2023 - "We examined the cytotoxic effects of the K+ ionophores, nigericin, nonactin, and valinomycin, on various B-lymphoma cells including PEL. "

Related Drugs and Biologics

1.	Interleukin-5 (Interleukin 5)
2.	Cyclosporine (Ciclosporin)
3.	Interleukin-4 (Interleukin 4)
4.	Valinomycin
5.	Nigericin
6.	Ionophores
7.	Interleukin-2 (IL2)
8.	Catenins
9.	Trypan Blue
10.	Monensin (Coban)