huperzine A

02/01/2020 - "oxyphylla significantly improved learning and memory ability of Alzheimer's disease (AD) mice, and AOP70 exhibited comparable or even better effects than huperzine A. "
06/01/2011 - "In human clinical trials, Huperzine A resulted in cognitive improvement in patients with mild to moderate form of Alzheimer's disease (AD) showing its potential as a palliative agent in the treatment of AD. "
12/01/2004 - "Huperzine A (HupA) is reported to increase efficiency for learning and memory in animals, and it shows promise in the treatment of Alzheimer's disease (AD). "
12/03/2022 - "Disease-Modifying Activity of Huperzine A on Alzheimer's Disease: Evidence from Preclinical Studies on Rodent Models."
02/08/2021 - "At present, Huperzine A (HupA) is one of the best drugs used for the treatment of Alzheimer's disease and has been used in clinical trials for several years in China. "

02/01/2019 - "[Efficacy and safety of huperzine A in treating patients with mild cognitive impairment: a systematic review and Meta-analysis]."
12/12/2012 - "Huperzine A for mild cognitive impairment."
01/01/2011 - "Laboratory guinea pigs were exposed to huperzine A at doses of 0, 5, 25, 125 and 625 µg/kg. The animals were observed for cognitive disorders and sacrificed one hour after exposure. "
02/01/1999 - "Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment."
01/01/1988 - "[Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment]."

11/09/2001 - "The protective effects of huperzine A on transient global ischemia in gerbils were investigated. "
11/09/2001 - "Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils."
11/09/2001 - "The ability of huperzine A to attenuate memory deficits and neuronal damage after ischemia might be beneficial in cerebrovascular type dementia."
09/13/2002 - "Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia."
06/09/2000 - "Daily oral administration of huperzine A produced a significant improvement of the deficit in the learning of the water maze task, beginning 28 days after ischemia, correlating to about 33-40% inhibition of acetylcholinesterase activity in cortex and hippocampus. "

12/01/2017 - "Huperzine A alleviates neuroinflammation, oxidative stress and improves cognitive function after repetitive traumatic brain injury."
12/19/2022 - "Huperzine-A Improved Animal Behavior in Cuprizone-Induced Mouse Model by Alleviating Demyelination and Neuroinflammation."
09/19/2016 - "Furthermore, therapeutic effects of the acetylcholinesterase inhibitor Huperzine A (HupA) on the hippocampal cholinergic nervous function and neuroinflammation were evaluated. "
04/01/2019 - "Huperzine A ameliorates cognitive dysfunction and neuroinflammation in kainic acid-induced epileptic rats by antioxidant activity and NLRP3/caspase-1 pathway inhibition."
06/08/2023 - "The nine plants (e.g., Ashwagandha, Adzuki bean, and olive) and 18 plant-derived substances (e.g., curcumin, Huperzine A, and Roxburgh's jewel orchid polysaccharides) included in this review improved obesity-induced cognitive impairment through several mechanisms, including attenuation of neuroinflammation, improvement in both central and peripheral insulin resistance, enhancement of neuroprotection and neurogenesis, and modulation of the synthesis and release of cognition-associated neurotransmitters. "

01/01/2004 - "Clinical trials of huperzine A in elderly patients with age-associated memory loss are underway in the US, and a phase II study funded by an NCI grant is being planned."
01/01/2015 - "It contains huperzine A, which has a protective effect against memory deficits in animal models; however, it is unclear if H. "
11/13/1995 - "Huperzine A (0.4-0.5 mg kg-1, i.p.) significantly ameliorated the AF64A-induced memory deficit. "
05/01/1991 - "[Drug evaluation of huperzine A in the treatment of senile memory disorders]."
04/01/2006 - "Oral administration of huperzine A (0.2 mg/kg, once per day, started 2 days before surgery and lasted for 7 days after surgery) markedly attenuated the memory deficits and neuronal damage. "