|1.||Uzan, Georges: 8 articles (09/2015 - 01/2010)|
|2.||Peng, Bin: 6 articles (09/2015 - 01/2010)|
|3.||Jeoung, Dooil: 5 articles (08/2015 - 06/2009)|
|4.||Zhang, Denghai: 5 articles (05/2015 - 01/2010)|
|5.||Moudgil, Kamal D: 5 articles (04/2015 - 04/2011)|
|6.||Venkatesha, Shivaprasad H: 5 articles (04/2015 - 04/2011)|
|7.||Yang, Bo: 5 articles (10/2014 - 01/2010)|
|8.||Zhu, Hong: 5 articles (10/2014 - 01/2010)|
|9.||Lu, Wei: 5 articles (01/2014 - 01/2010)|
|10.||Sethi, Gautam: 5 articles (04/2012 - 04/2007)|
10/01/2014 - "In this report, we demonstrated that the combination of celastrol and SAHA exerted substantial synergistic efficacy against human cancer cells in vitro and in vivo accompanied by enhanced caspase-mediated apoptosis. "
09/27/2013 - "The objective of this in vitro study was to silence inducible Hsp70 and to promote celastrol-induced tumor cell death. "
01/01/2013 - "The purpose of this study was to evaluate the antitumor effect of cell-penetrating peptide-coated tripterine-loaded nanostructured lipid carriers (CT-NLC) on prostate tumor cells in vitro and in vivo. "
05/01/2012 - "In the present study, we found that celastrol, a natural compound with well-known apoptosis-inducing effect, could also induce paraptosis-like cytoplasmic vacuolization in cancer cell lines including HeLa cells, A549 cells and PC-3 cells derived from cervix, lung and prostate, respectively. "
08/01/2011 - "In this study, the cytotoxicity of celastrol for HepG2 cancer cells was firstly explored. "
01/01/2013 - "Taken together, celastrol treatment not only improved insulin resistance, glycemic control and oxidative stress, but also improved renal functional and structural changes through both metabolic and anti-inflammatory effects in the kidney. "
01/01/2014 - "In the present study, we sought to investigate the direct effects of celastrol (potent NF-κB inhibitor) upon mitochondrial dysfunction-induced insulin resistance in 3T3-L1 adipocytes. "
01/01/2015 - "Taken together, these results suggest that celastrol may be advocated for use as a potential therapeutic molecule to protect against mitochondrial dysfunction-induced insulin resistance in human skeletal muscle cells. "
01/01/2013 - "Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice."
10/06/2015 - "Genetic modulation of HSF1 levels altered white fat remodeling and thermogenesis, and pharmacological activation of HSF1 via celastrol was associated with enhanced energy expenditure, increased mitochondrial function in fat and muscle and protection against obesity, insulin resistance, and hepatic steatosis during high-fat diet regimens. "
03/01/2013 - "Here, we demonstrate that celastrol, but not classical heat shock treatment, is effective in inducing a set of neuroprotective Hsps in cultures derived from cerebral cortices, including Hsp70, Hsp27 and Hsp32. "
07/01/2015 - "Pre-incubation with celastrol, an HSP90 inhibitor that promotes heat shock gene expression, slightly up-regulated expression of both hsp-1 and daf-21 during heat shock. "
03/01/2008 - "Transcriptional profiling revealed that celastrol treatment induces a battery of oxidant defense genes in addition to heat shock genes. "
03/01/2008 - "Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule."
12/31/2004 - "Celastrol can activate heat shock gene transcription synergistically with other stresses and exhibits cytoprotection against subsequent exposures to other forms of lethal cell stress. "
10/06/2015 - "The beneficial metabolic changes elicited by celastrol were abrogated in HSF1 knockout mice. Overall, our findings identify the temperature sensor HSF1 as a regulator of energy metabolism and demonstrate that augmenting HSF1 via celastrol represents a possible therapeutic strategy to treat obesity and its myriad metabolic consequences. "
10/06/2015 - "Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis."
05/21/2015 - "Here, by using in silico drug-screening methods, we discovered that Celastrol, a pentacyclic triterpene extracted from the roots of Tripterygium Wilfordi (thunder god vine) plant, is a powerful anti-obesity agent. "
05/21/2015 - "Treatment of obesity with celastrol."
12/05/2014 - "Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism."
12/01/2015 - "Taken together, our results demonstrated that celastrol exerted beneficial effects in colitis treatment via suppressing the RIP3/MLKL necroptosis pathway. "
12/01/2015 - "Celastrol was administered intraperitoneally (1mg/kg) for 7days after colitis was induced. "
12/01/2015 - "Celastrol, a triterpene from the root bark of the Chinese medicinal plant Tripterygium wilfordii, has been reported to have anti-oxidant and anti-inflammatory activities in colitis. "
03/05/2014 - "Here, we investigated the effect of the novel NF-κB inhibitor celastrol on murine colitis. "
05/01/2015 - "Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy by suppressing the PI3K/Akt/mTOR signaling pathway."
|3.||Protein Isoforms (Isoforms)
|4.||Interleukin-10 (Interleukin 10)
|8.||Collagen Type IV (Type IV Collagen)
|9.||Tissue Inhibitor of Metalloproteinase-2
|10.||Tissue Inhibitor of Metalloproteinase-1
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Chinese Traditional Medicine (Traditional Chinese Medicine)
|4.||Drug Therapy (Chemotherapy)