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DIAM 4
aziridine derivative of a cyclophosphazene cpd; tested for treatment of lupus diseases; structure given in first source
Also Known As:
1,3,5,7,12-Pentaaza-2,4,6-triphospha(6-PV)spiro(5.6)dodeca-1,3,5-triene, 2,2,4,4-tetrakis(1-aziridinyl)-2,2,4,4-tetrahydro-; DIAM4
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azirines
Aziridines: 14
DIAM 4: 2
Organic Chemicals: 133
Organophosphorus Compounds: 300
DIAM 4: 2
Related Diseases
1.
Proteinuria
06/01/1990 - "
DIAM4 induces the disappearance of the lymphoproliferation, the increase in C3 levels and the decrease in anti-DNA antibody, immunoglobulin and urea levels, and proteinuria.
"
2.
Lupus Nephritis
07/01/1992 - "
The usefulness of such a model for in vivo evaluation of immunomodulatory and therapeutic effects of drugs, was investigated by treating mice with DIAM4, a cyclophosphazenic compound known to modulate polyclonal activation of lymphocytes and to prevent mouse lupus nephritis.
"
Related Drugs and Biologics
1.
Therapeutic Uses
2.
Urea (Carbamide)
3.
Immunoglobulins (Immunoglobulin)
4.
DNA (Deoxyribonucleic Acid)