1,3-ditolylguanidine

structure given in first source; a selective ligand for the sigma binding sites in the brain

Also Known As:

1,3-di-(2-tolyl)guanidine; 1,3-di-o-tolylguanidine; 1,3-di-ortho-tolyl-guanidine; 1,3-ditolylguanidine hydrochloride; N,N'-bis(2-methylphenyl)guanidine

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - 1,3-ditolylguanidine: 11

Experts

1.	Inácio, Ana R: 1 article (01/2012)
2.	Kuric, Enida: 1 article (01/2012)
3.	Rowshan Ravan, Arman: 1 article (01/2012)
4.	Ruscher, Karsten: 1 article (01/2012)
5.	Valind, Kristian: 1 article (01/2012)
6.	Wieloch, Tadeusz: 1 article (01/2012)
7.	Collier, Lisa A: 1 article (06/2010)
8.	Green, Suzanne M: 1 article (06/2010)
9.	Hall, Aaron A: 1 article (06/2010)
10.	Leonardo, Christopher C: 1 article (06/2010)

Related Diseases

1.	Shock 10/01/1997 - "The present study was designed to investigate the effects of the mu-opioid morphine, trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)- cyclohexyl]-benzene acetamide, methane sulfonate hydrate (U-50488H), a kappa-selective opioid receptor agonist, and 1,3-di-(2-tolyl)guanidine (DTG), sigma-receptor agonist, on the discriminative stimulus properties of cocaine in the rat trained to discriminate 10 mg/kg of cocaine from its vehicle in a shock avoidance paradigm. "
2.	Dystonia (Limb Dystonia) 01/01/1999 - "To clarify which subtype of sigma receptors is involved in the sigma receptor-mediated neck dystonia in rats, we examined whether 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503), a selective sigma1 receptor agonist, and 1,3-di-(2-tolyl)guanidine (DTG), a sigma1 and sigma2 receptor agonist, induce neck dystonia in rats. " 06/01/1988 - "1,3-Di-o-tolylguanidine (DTG), a highly selective ligand for the haloperidol-sensitive sigma-receptor, produced marked dystonia in rats after microinjection into the red nucleus, a motor area rich in this receptor. "
3.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 06/01/2010 - "Previously, delayed administration of the sigma receptor agonist 1,3-di-o-tolylguanidine (DTG) reduced infarct volume after middle cerebral artery occlusion (MCAO) in rats. "
4.	Schizophrenia (Dementia Praecox) 03/23/1993 - "The sigma receptor ligand 1,3-di-(2-tolyl)guanidine in animal models of schizophrenia."
5.	Pain (Aches) 09/01/1995 - "1,3-Di-o-tolylguanidine (DTG) differentially affects acute and tonic formalin pain: antagonism by rimcazole."

Related Drugs and Biologics

1.	sigma Receptors (sigma Receptor)
2.	Opioid Receptors (Opioid Receptor)
3.	Morphine (MS Contin)
4.	Cocaine (Cocaine HCl)
5.	Benzene (Benzole)
6.	Opioid Analgesics (Opioids)
7.	acetamide
8.	Ligands
9.	SA 4503
10.	rimcazole