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LG 30435
derivative of mequitazine
Also Known As:
1-Azoniabicyclo(2.2.2)octane, 1-methyl-3-(10H-phenothiazin-10-ylmethyl)-, iodide; 3-(10-H-phenothiazinylmethyl)-1-methyl-1-azabicyclo(2.2.2)octane; LG-30435; d-Meq cpd; mequitaminum iodide
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Phenothiazines: 506
LG 30435: 4
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Phenothiazines: 506
LG 30435: 4
Related Diseases
1.
Asthma (Bronchial Asthma)
11/01/1986 - "
These results show that LG 30435 is endowed with a peculiar anti-PAF action, which may be advantageous in the treatment of asthma.
"
10/01/1989 - "
These data, which further substantiate the bronchodilator activity of LG 30435 against a variety of stimuli and demonstrate its protective properties on lung anaphylaxis, suggest that this compound has a potential therapeutic value in the treatment of asthma.
"
11/01/1986 - "
Since PAF-acether (PAF) is a potential mediator of asthma, LG 30435 was assayed for its ability to counteract PAF-induced platelet aggregation (PA) in rabbit platelet rich plasma and bronchoconstriction (BC) in anaesthetized guinea-pigs, in comparison with other antihistamines.
"
2.
Anaphylaxis (Anaphylactic Shock)
04/01/1988 - "
LG 30435 (N-methylmequitazine) was assayed in passive lung (PLA) and cutaneous (PCA) anaphylaxis in guinea-pigs and rats.
"
10/01/1989 - "
These data, which further substantiate the bronchodilator activity of LG 30435 against a variety of stimuli and demonstrate its protective properties on lung anaphylaxis, suggest that this compound has a potential therapeutic value in the treatment of asthma.
"
3.
Bronchial Spasm
07/15/1986 - "
LG 30435 also counteracted antigen-induced bronchospasm both in passively sensitized guinea-pigs and in actively sensitized rats.
"
07/15/1986 - "
LG 30435, a new quaternary derivative of the H1-histamine antagonist mequitazine, was evaluated against bronchospasm induced by different agonists.
"
07/15/1986 - "
When administered to guinea-pig by the i.v. and/or the aerosol route, LG 30435 inhibited dose dependently the bronchospasm induced by acetylcholine and histamine and to a lesser degree that induced by 5-hydroxytryptamine and LTD4.
"
Related Drugs and Biologics
1.
Leukotriene D4
2.
Serotonin (5 Hydroxytryptamine)
3.
Platelet Activating Factor
4.
Histamine Antagonists (Antihistamines)
5.
Histamine (Histamine Dihydrochloride)
6.
Bronchodilator Agents (Bronchodilators)
7.
Antigens
8.
Aerosols
9.
Acetylcholine (Acetylcholine Chloride)
10.
mequitazine