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Y 20811
structure given in first source
Also Known As:
4-(alpha-hydroxy-5-(1-imidazolyl)-2-methylbenzyl)-3,5-dimethylbenzoic acid; Y-20811; Benzoic acid, 4-(hydroxy(5-(1H-imidazol-1-yl)-2-methylphenyl)methyl)-3,5-dimethyl-, monosodium salt
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Y 20811: 6
Related Diseases
1.
Infarction (Infarctions)
05/01/1993 - "
Y-20811 significantly suppressed the infarction number and the incidence at doses of 1 mg/kg and 10 mg/kg (p.o.), respectively.
"
03/01/1993 - "
Thus, Y-20811 reduced reperfusion arrhythmias but failed to limit infarct size and neutrophil accumulation after coronary artery occlusion/reperfusion in dogs.
"
03/01/1993 - "
To examine effects of a new thromboxane synthetase inhibitor, Y-20811, on infarct size, neutrophil accumulation, and arrhythmias, coronary artery was occluded for 90 min and reperfused for 6 h in anesthetized dogs.
"
03/01/1993 - "
Effects of a thromboxane synthetase inhibitor, Y-20811, on infarct size, neutrophil accumulation, and arrhythmias after coronary artery occlusion and reperfusion in dogs.
"
05/01/1993 - "
Aspirin significantly inhibited the infarction number at a dose of 10 mg/kg, but its inhibitory effect decreased at 30 mg/kg. Ticlopidine showed no effect even at a dose of 300 mg/kg. These results indicate that Y-20811 may be useful in preventing embolic cerebral infarction and transient ischemic attacks.
"
2.
Intracranial Embolism
05/01/1993 - "
Effect of Y-20811, a thromboxane synthetase inhibitor, on photochemically induced cerebral embolism in rabbits.
"
05/01/1993 - "
The effect of Y-20811, a selective thromboxane A2 synthetase inhibitor, was investigated on cerebral embolism using a new model of embolic cerebral infarction in rabbits.
"
3.
Thrombosis (Thrombus)
07/01/1992 - "
The experiments indicate that Y-20811 has an inhibitory effect on platelet thrombus formation following intimal injury, but subsequent myointimal thickening is not inhibited by the drug.
"
07/01/1992 - "
Inhibitory effect of Y-20811 on platelet thrombus formation induced by mechanical intimal injury and subsequent intimal fibrous thickening was studied.
"
07/01/1992 - "
Effects of antithrombotic drug, Y-20811 on mural thrombus formation and intimal thickening following intimal injury.
"
4.
Septic Shock (Toxic Shock Syndrome)
02/15/1990 - "
These results indicate that Y-20811 is useful in treating endotoxin shock.
"
02/15/1990 - "
Protective effect of Y-20811, a long-lasting thromboxane synthetase inhibitor, on endotoxin shock in rabbits.
"
5.
Respiratory Hypersensitivity
01/01/1991 - "
Y-20811 (0.3-3 mg/kg) administered orally 3 h prior to challenge inhibited this airway hyperresponsiveness in a dose-dependent manner.
"
01/01/1991 - "
Effect of Y-20811 on airway hyperresponsiveness was studied in sensitized guinea pigs.
"
01/01/1991 - "
These results suggest that Y-20811 suppress the asthmatic mechanism which causes antigen-induced airway hyperresponsiveness.
"
01/01/1991 - "
Y-20811 (3 mg/kg) administered orally 4 h after antigen challenge also decreased the airway hyperresponsiveness.
"
01/01/1991 - "
Effect of Y-20811, a long-lasting thromboxane A2 synthetase inhibitor, on antigen-induced airway hyperresponsiveness in guinea pigs.
"
Related Drugs and Biologics
1.
Thromboxane-A Synthase
2.
Ticlopidine (Ticlid)
3.
Thromboxane B2
4.
Thromboxane A2 (A2, Thromboxane)
5.
Ligases (Synthetase)
6.
Aspirin (Acetylsalicylic Acid)
7.
Antigens
8.
prostaglandin F1