HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

5-hydroxymethylomeprazole

metabolite of omeprazole

Also Known As:

5-hydroxy omeprazole; 5-methoxy-2-(((4-methoxy-3-methyl-5-hydroxymethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole; hydroxyomeprazole

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfoxides: 23
    - 2-Pyridinylmethylsulfinylbenzimidazoles
      - 5-hydroxymethylomeprazole: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 2-Pyridinylmethylsulfinylbenzimidazoles
      - 5-hydroxymethylomeprazole: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 2-Pyridinylmethylsulfinylbenzimidazoles
        5-hydroxymethylomeprazole: 3

Experts

1.	Andersson, Shalini: 1 article (01/2022)
2.	Andersson, Tommy B: 1 article (01/2022)
3.	Artursson, Per: 1 article (01/2022)
4.	Bachmann, Fabio: 1 article (01/2022)
5.	Bouitbir, Jamal: 1 article (01/2022)
6.	Christensen, Hege: 1 article (01/2022)
7.	Duthaler, Urs: 1 article (01/2022)
8.	Grandinetti, Tanja: 1 article (01/2022)
9.	Haschke, Manuel: 1 article (01/2022)
10.	Heijer, Maria: 1 article (01/2022)

Related Diseases

1.	Gastroesophageal Reflux (GERD) 12/01/2005 - "In a second trial plasma levels of esomeprazole and corresponding CYP2C19 and CYP3A4 metabolites (5-hydroxyomeprazole and omeprazole sulfone) were monitored in 10 CYP2C19 wild-type patients with GERD after the first and last doses (day 7) of 40 mg esomeprazole daily to calculate metabolic ratios. "
2.	Overweight 01/01/2022 - "The objective was to compare short- and long-term effects of RYGB and diet on the metabolic ratios of paraxanthine/caffeine (cytochrome P450 [CYP] 1A2 activity), 5-hydroxyomeprazole/omeprazole (CYP2C19 activity) and losartan/losartan carboxylic acid (CYP2C9 activity), and cross-sectionally compare these CYP-activities with normal-to-overweight controls. "
3.	Fibrosis (Cirrhosis) 01/01/2022 - "In patients with Child C cirrhosis, the metabolic ratio (ratio of the area under the plasma concentration-time curve from 0 to 24 h of the metabolite to the parent compound), a marker for CYP activity, decreased by 66%, 47%, 92%, 73%, and 43% for paraxanthine/caffeine (CYP1A2), 8-hydroxyefavirenz/efavirenz (CYP2B6), 5-hydroxyomeprazole/omeprazole (CYP2C19), α-hydroxymetoprolol/metoprolol (CYP2D6), and 1'-hydroxymidazolam/midazolam (CYP3A), respectively. "

Related Drugs and Biologics

1.	Cytochrome P-450 CYP2C19
2.	Cytochrome P-450 CYP3A
3.	Esomeprazole (Nexium)
4.	omeprazole sulfone
5.	Cytochrome P-450 CYP1A2 (CYP1A2)
6.	Omeprazole (Prilosec)
7.	Caffeine (No Doz)
8.	1,7-dimethylxanthine (paraxanthine)
9.	Cytochrome P-450 CYP2C9
10.	Cytochrome P-450 CYP2B6 (CYP2B6)