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diproteverine

Also Known As:

1-((3,4-diethoxyphenyl)methyl)-3,4-dihydro-6,7-bis(1-methylethoxy)isoquinoline HCL; BRL 40015A; BRL-40015-A; BRL-40015A; diproteverine hydrochloride

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - diproteverine: 2

Related Diseases

1.	Angina Pectoris 01/17/1991 - "The combination of the reduction in heart rate, to lower cardiac oxygen demand, with the beneficial action on coronary blood flow should result in diproteverine being particularly beneficial for the treatment of angina pectoris."
2.	Congenital Heart Defects (Congenital Heart Defect) 01/01/1996 - "In prenatal toxicity studies, diproteverine, a calcium channel blocker with demonstrated antianginal properties, produced an unusual pattern of digital, heart, tail, and vertebral defects in rat fetuses from mothers treated during the major period of organogenesis, but only a very low incidence of heart abnormalities was seen in the rabbit. "
3.	Tachycardia (Tachyarrhythmias) 01/17/1991 - "This appeared to be a particular feature of diproteverine as the other calcium antagonists studied produced either a smaller decrease in heart rate or tachycardia as a reflex response to hypotension. "
4.	Myocardial Infarction 01/17/1991 - "In a chronic myocardial infarct model in dogs, diproteverine caused a redistribution of the available coronary blood flow, to the benefit of an ischaemic area of the myocardium. "
5.	Hypotension (Low Blood Pressure) 01/17/1991 - "This appeared to be a particular feature of diproteverine as the other calcium antagonists studied produced either a smaller decrease in heart rate or tachycardia as a reflex response to hypotension. "

Related Drugs and Biologics

1.	Oxygen (Dioxygen)
2.	Calcium Channel Blockers (Blockers, Calcium Channel)
3.	Calcium