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tetraplatin (ormaplatin)

structure given in first source
Also Known As:
ormaplatin; 1,2-diaminocyclohexane tetrachloroplatinum(IV); NSC 363812; NSC-363812; tetrachloro-1,2-diaminocyclohexane Pt(IV)
Networked: 48 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Koukourakis, Michael I: 1 article (12/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Leukemia L1210
04/29/1994 - "We have studied the effect of extracellular reduced glutathione (GSH) on the cytotoxicity and biochemical pharmacology of tetraplatin in L1210 leukemia cells. "
01/01/1987 - "trans-Tetrachloro-1,2-diaminocyclohexane platinum (IV) (tetraplatin) was therapeutically effective in mice bearing leukemia L1210 resistant (L1210/DDPt) or sensitive (L1210/0) to cis-diamminedichloroplatinum (II) (cisplatin). "
07/01/1994 - "Three homologous alicyclic mixed amine cis-(NH3)(R-NH2)Cl2Pt(II) complexes, in which R = C3H5, C6H11, and C8H15 (complexes abbreviated C3, C6, and C8, respectively), were evaluated with reference compounds cisplatin and tetraplatin for antitumor activities and biochemical pharmacology in wild-type (murine leukemia L1210/0 and human ovarian A2780) and corresponding variant cell lines resistant to cisplatin (L1210/DDP and 2780CP) and tetraplatin (L1210/DACH and 2780TP). "
04/01/1993 - "We have examined each of the three individual isomers of DACH-Cl4-Pt(IV) with respect to cytotoxicity, uptake of platinum and total DNA-platinum in three murine leukemia L1210 (cisplatin-sensitive L1210/0, 50-fold cisplatin-resistant L1210/DDP and 36-fold tetraplatin-resistant L1210/DACH) and human ovarian carcinoma A2780 (cisplatin-sensitive) and A2780cp (8-fold cisplatin-resistant) cell lines. "
12/01/1994 - "A platinum(II) and three platinum(IV) ammine/cycloalkylamine homologous series, the latter possessing either chloro, acetato or hydroxo axial ligands, were evaluated for efficacies in mice bearing tumor cells sensitive (leukemia L.1210/0 and reticulosarcoma M5076) or resistant to cisplatin (L1210/DDP) and tetraplatin (L1210/DACH). "
3. Carcinoma (Carcinomatosis)
4. Leukemia
5. Fibrosarcoma

Related Drugs and Biologics

1. Cisplatin (Platino)
2. Platinum
3. Carboplatin (JM8)
4. Amifostine (Ethyol)
5. buthionine
6. 1,2-cyclohexanediamine (dach)
7. tetraplatin (ormaplatin)
8. iproplatin (JM9)
9. oxaliplatin (Eloxatin)
10. DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Injections
3. Drug Therapy (Chemotherapy)