evodiamine

10/01/2013 - "Together, these results indicate that the SPION-evodiamine-loaded nanocarrier could effectively inhibit tumor growth both in vitro and in vivo with reduced toxicity, and therefore is a promising candidate to achieve enhanced therapeutic efficacy for clinical development. "
01/01/2012 - "Evodiamine has therapeutic potential against cancers. "
02/01/2019 - "In previous studies, WZY-321 (10-hydroxy-1-methyl-8,13b-dihydro-5H,7H-benzo[e]benzofuro[2',3':3,4]pyrido[2,1-b][1,3]oxazin-5-one), a novel evodiamine (Evo) analog, was reported to exhibit enhanced pharmacological properties and improved cytotoxicity against a number of human cancer cell lines compared with Evo. "
09/19/2022 - "Based on these results, we expect that the results from this study will further elucidate our understanding of evodiamine as an anti-cancer drug."
09/05/2022 - "In this work, a comprehensive SAR study on evodiamine scaffold with N14-3'-fluorophenyl substituted was completed, and compounds with high anti-tumor activity and good inhibitory effect on Top1 and Top2 were screened out. "

03/25/2021 - "Evodiamine Inhibits Helicobacter pylori Growth and Helicobacter pylori-Induced Inflammation."
01/01/2019 - "Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-κB-Mediated Inflammation."
02/01/2022 - "All the results suggested that evodiamine inhibited inflammation by inhibiting the phosphorylation of AKT, NF-κBp65, ERK1/2, p38, and JNK thus the LPS-induced mastitis was ameliorated. "
06/01/2020 - "Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance."
01/01/2020 - "Evodiamine reduced peripheral hypersensitivity on the mouse with nerve injury or inflammation."

12/01/2004 - "Protective effects of evodiamine on myocardial ischemia-reperfusion injury in rats."
12/01/2004 - "In the present study, we have examined whether evodiamine protects against myocardial ischemia-reperfusion injury in rats and whether the protective effects of evodiamine are related to the activation of capsaicin-sensitive sensory nerves. "
12/01/2004 - "These results suggest that evodiamine exerts a protection against myocardial ischemia-reperfusion injury in rats and that the protective effects of evodiamine are related to stimulation of CGRP release via activation of vanilloid receptors."
11/10/2015 - "In addition, the results of in vivo pharmacological trials revealed that rutaecarpine (1.1mg/ml) and evodiamine (1.1mg/ml) attenuated myocardial infarct size injured by myocardial ischemia/reperfusion, improved metabolism disorders between fatty acid and glucose, increased the content of ATP, Ca(2+)-ATPase activity and reduced the content of peroxisome proliferator-activated receptor α (PPARα) protein level. "

01/01/2022 - "Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects."
01/01/2020 - "Evodiamine has therapeutic efficacy in ulcerative colitis by increasing Lactobacillus acidophilus levels and acetate production."

01/01/2014 - "Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine."
08/20/2019 - "Development of EGFR-targeted evodiamine nanoparticles for the treatment of colorectal cancer."
01/01/2019 - "Evodiamine inhibits migration and invasion by Sirt1-mediated post-translational modulations in colorectal cancer."
06/01/2016 - "Evodiamine Suppresses ABCG2 Mediated Drug Resistance by Inhibiting p50/p65 NF-κB Pathway in Colorectal Cancer."
11/16/2015 - "Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells."