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2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridine

mutagen from fried ground beef; structure given in first source
Also Known As:
PhIP
Networked: 351 relevant articles (7 outcomes, 56 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Nakagama, Hitoshi: 14 articles (01/2014 - 01/2002)
2. Snyderwine, Elizabeth G: 13 articles (01/2007 - 01/2002)
3. Sugimura, Takashi: 12 articles (09/2009 - 01/2002)
4. Sinha, Rashmi: 11 articles (10/2015 - 09/2002)
5. Yu, Minshu: 10 articles (04/2005 - 05/2002)
6. Ochiai, Masako: 9 articles (01/2014 - 01/2002)
7. Shirai, Tomoyuki: 9 articles (08/2013 - 01/2002)
8. Shirai, T: 9 articles (07/2006 - 03/2000)
9. Turesky, Robert J: 8 articles (08/2015 - 05/2002)
10. Hirose, Masao: 7 articles (04/2006 - 01/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Aberrant Crypt Foci
3. Prostatic Neoplasms (Prostate Cancer)
4. Colorectal Neoplasms (Colorectal Cancer)
5. Hepatocellular Carcinoma (Hepatoma)
06/01/2010 - "We compared the effects of two of the most common HAA, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), individually or in combination, in the metabolically competent human hepatoma HepaRG cells. "
03/01/2012 - "Protective effects of xanthohumol against the genotoxicity of heterocyclic aromatic amines MeIQx and PhIP in bacteria and in human hepatoma (HepG2) cells."
01/01/2011 - "The aim of the present study was to evaluate the protective effect of (+)-catechin and (-)-epicatechin against 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline (8-MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]-quinoxaline (4,8-diMeIQx) and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP)-induced DNA damage in human hepatoma cells (HepG2). "
08/01/2003 - "Effect of chrysin, a flavonoid compound, on the mutagenic activity of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and benzo(a)pyrene (B(a)P) in bacterial and human hepatoma (HepG2) cells."
11/01/1999 - "In order to study the mutagenic effects of heterocyclic aromatic amines (HAAs) in cells of human origin, five compounds, namely 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ), 2-amino-3, 4-dimethyl-imidazo[4,5-f]quinoline (MeIQ), 2-amino-3, 8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx), the pyridoimidazo derivative 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), were tested in micronucleus (MN) assays with a human derived hepatoma (HepG2) cell line. "

Related Drugs and Biologics

1. benzocycloheptapyridine
2. Amines
3. Carcinogens
4. Curcumin
5. Aligeron (AS 2)
6. Palmitates
7. Coffee
8. xanthohumol
9. kahweol
10. cafestol

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1. Prostatectomy (Retropubic Prostatectomy)
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4. Oral Administration
5. Caloric Restriction