anguibactin

a peptide biosynthesized by nonribosomal peptide synthetases; siderophore isolated from Vibrio anguillarum 775 harboring the pJM1 plasmid

Also Known As:

4-Thiazolecarboxamide, 2-(2,3-dihydroxyphenyl)-4,5-dihydro-N-hydroxy-N-(2-(1H-imidazol-4-yl)ethyl)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - anguibactin: 5

Experts

1.	Crosa, Jorge H: 2 articles (02/2010 - 11/2004)
2.	Blunt, John: 1 article (06/2010)
3.	Butler, Alison: 1 article (06/2010)
4.	Han, Andrew: 1 article (06/2010)
5.	Haygood, Margo: 1 article (06/2010)
6.	Munro, Murray: 1 article (06/2010)
7.	Sandy, Moriah: 1 article (06/2010)
8.	López, Claudia S: 1 article (02/2010)
9.	Naka, Hiroaki: 1 article (02/2010)
10.	Balado, Miguel: 1 article (05/2009)

Related Diseases

1.	Vibrio Infections 05/01/2009 - "We found that fvtA and vanchrobactin biosynthesis genes are ubiquitous in both vanchrobactin- and anguibactin-producing V. anguillarum strains, which reinforces the utility of the vanchrobactin route of entry for the design of future strategies for the control of vibriosis."
2.	Starvation 01/01/1995 - "The presence of anguibactin was also demonstrated in supernatants from cultures of the hdc mutant strains grown under iron starvation with the addition of histamine, further confirming that histamine is a precursor in the biosynthesis of the siderophore.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/1995 - "The role of histidine decarboxylase in biosynthesis of anguibactin was confirmed by the fact that growth under iron starvation was restored by addition of histamine to the medium. "
3.	Leukemia 06/25/2010 - "In addition to siderophore production, extracts of Vibrio sp. DS40M4 were screened for biologically active molecules; anguibactin was found to be cytotoxic against the P388 murine leukemia cell line (IC(50) < 15 microM)."
4.	Infections 11/01/2004 - "The mutations in angM that affected anguibactin production also resulted in a dramatic attenuation of the virulence of V. anguillarum 775, highlighting the importance of this gene in the establishment of a septicemic infection in the vertebrate host. "
5.	Hemorrhagic Septicemia (Haemorrhagic Septicemia) 02/01/2010 - "Vibrio anguillarum serotype O1 is part of the natural flora in the aquatic habitat, but under certain circumstances it can cause terminal haemorrhagic septicemia in marine and fresh water fish due to the action of the anguibactin iron uptake system encoded by the virulence plasmid pJM1. "

Related Drugs and Biologics

1.	Siderophores
2.	Iron
3.	Histidine Decarboxylase
4.	Histamine (Histamine Dihydrochloride)
5.	vanchrobactin