PVDA protocol

chemotherapy protocol consisting of above cpds; used in treatment of acute lymphoblastic leukemia

Also Known As:

BFM protocol; BMF phase I protocol; Berlin-Frankfort-Munster protocol; phase I Bonn-Munich-Frankfurt protocol

Networked: 34 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Combination Drug Therapy: 12066
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - PVDA protocol: 34
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - PVDA protocol: 34
- Clinical Protocols
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - PVDA protocol: 34
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Amidohydrolases: 43
      - Asparaginase: 2285
        PVDA protocol: 34
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthacenes
        Anthracyclines: 9423
        Daunorubicin: 2641
        PVDA protocol: 34
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthacenes
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        PVDA protocol: 34
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienediols
        Prednisone: 12650
        PVDA protocol: 34
Carbohydrates: 22023
- Glycosides: 2119
  - Aminoglycosides: 5131
    - Anthracyclines: 9423
      - Daunorubicin: 2641
        PVDA protocol: 34
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Secologanin Tryptamine Alkaloids: 81
      - Vinca Alkaloids: 463
        Vincristine: 9251
        PVDA protocol: 34
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Vinca Alkaloids: 463
        Vincristine: 9251
        PVDA protocol: 34
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Vinca Alkaloids: 463
        Vincristine: 9251
        PVDA protocol: 34

Experts

1.	Apak, Hilmi: 3 articles (03/2021 - 10/2010)
2.	Avgeris, Margaritis: 3 articles (11/2018 - 09/2017)
3.	Baka, Margarita: 3 articles (11/2018 - 09/2017)
4.	Gourgiotis, Dimitrios: 3 articles (11/2018 - 09/2017)
5.	Marmarinos, Antonios: 3 articles (11/2018 - 09/2017)
6.	Piatopoulou, Despina: 3 articles (11/2018 - 09/2017)
7.	Scorilas, Andreas: 3 articles (11/2018 - 09/2017)
8.	Xagorari, Marieta: 3 articles (11/2018 - 09/2017)
9.	Celkan, Tiraje: 2 articles (03/2021 - 06/2014)
10.	Koka, Aida: 2 articles (03/2021 - 06/2014)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 08/16/2018 - "ETV6/RUNX1-positive childhood acute lymphoblastic leukemia in China: excellent prognosis with improved BFM protocol." 03/01/2021 - "The aim of this study is to compare the outcome of children with acute lymphoblastic leukemia treated with BFM protocol over two decades at our center. " 07/01/2018 - "In the present study, we examined the expression profile of miR-143 and miR-182 in childhood ALL and evaluated their clinical significance for patients receiving Berlin-Frankfurt-Münster (BFM) protocol. " 09/05/2017 - "In this study, we analysed miR-125b expression in childhood ALL and evaluated its clinical utility for patients treated with Berlin-Frankfurt-Münster (BFM) protocol. " 01/01/1987 - "Treatment of acute lymphoblastic leukemia in children with the BFM protocol: a cooperative study and analysis of prognostic factors."
2.	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 07/01/2011 - "ALCL99 protocol including six courses of chemotherapy derived from the NHL-BFM protocol is widely used for the treatment of paediatric anaplastic large-cell lymphoma. "
3.	Burkitt Lymphoma (Burkitt's Lymphoma) 10/01/2010 - "This study aimed to assess the demographic data and treatment results of children who were diagnosed with Burkitt lymphoma and treated according to the Berlin-Frankfurt-Münster-95 (BFM) protocol in a single institution. " 01/01/2021 - "Treatment results of modified BFM protocol in pediatric high-risk Burkitt lymphoma." 04/01/2002 - "We have treated eight patients with Burkitt's lymphoma with a modified BFM protocol. " 04/01/2002 - "Burkitt's lymphoma: single-centre experience with modified BFM protocol."
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 02/01/2013 - "In this paper, we review four successive studies on the basis of acute myeloid leukemia-Berlin-Frankfurt-Munster (AML-BFM) protocol, in which a stepwise improvement of treatment outcome was observed. " 01/01/1987 - "Five children treated for acute myeloid leukemia according to the BFM protocol AML 83 experienced first bone marrow relapse after 7, 10, 14, 18, and 30 months and were retreated for second remission induction. "
5.	Venous Thromboembolism 08/01/2001 - "Recently published data suggest that the prothrombin G20210A variant, the TT677 methylenetetrahydrofolate reductase genotype, the factor V G1691A mutation, deficiencies of protein C, protein S, antithrombin, and elevated lipoprotein (a) concentrations were associated with venous thromboembolism in childhood patients treated according to the BFM protocol. "

Related Drugs and Biologics

1.	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
2.	Excitatory Amino Acids
3.	Protein S
4.	Lipoprotein(a)
5.	tau Proteins (tau Protein)
6.	Steroids
7.	Prothrombin (Factor II)
8.	Protein C
9.	Hemostatics (Antihemorrhagics)
10.	Antithrombins

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Remission Induction