|1.||Kim, Sang Geon: 2 articles (01/2009 - 05/2008)|
|2.||Pietsch, Kathryn E: 1 article (11/2012)|
|3.||Erzinger, Melanie M: 1 article (11/2012)|
|4.||Whang, John: 1 article (11/2012)|
|5.||Niederhuber, John: 1 article (11/2012)|
|6.||Cervoni-Curet, Frances N: 1 article (11/2012)|
|7.||Yu, Xiang: 1 article (11/2012)|
|8.||Sturla, Shana J: 1 article (11/2012)|
|9.||Kensler, Thomas W: 1 article (08/2009)|
|10.||Fishbein, James C: 1 article (08/2009)|
01/01/2009 - "4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (oltipraz), a prototype drug candidate containing a 1,2-dithiole-3-thione moiety, has been widely studied as a cancer chemopreventive agent. "
11/01/1996 - "Treatment of rats with the cancer chemopreventive agent 1,2-dithiole-3-thione (D3T) resulted in a significant increase in hepatic heme oxygenase (HO) activity, which corresponded to increased protein levels of HO-1. "
01/01/1993 - "Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties."
01/01/1992 - "In this study, levels of molecular dosimetry biomarkers for determining genotoxic damage caused by aflatoxin B1 have been measured in a chronic exposure model with male F344 rats wherein half the animals were fed a diet supplemented with 0.03% 1,2-dithiole-3-thione to lower their risk for tumors and the other half were fed unsupplemented AIN-76A diet and were at high risk for tumor development. "
08/01/2009 - "The ability of three dithiolethione cancer chemopreventives, oltipraz 1, anetholedithione (ADT) 2, 1,2-dithiole-3-thione (D3T) 3, and the major metabolite, 4, of 1, to induce the cytoprotective enzyme NQO1 in Hepa 1c1c7 cells and the inhibition of this induction by catalase are demonstrated. "
|2.||Liver Neoplasms (Liver Cancer)
01/01/1997 - "We showed that 1,2-dithiole-3-thione (D3T) can increase the level of DT-diaphorase activity and the cytotoxic activity of bioreductive agents in mouse lymphoma cells without increasing these activities in normal mouse marrow cells. "
07/01/1996 - "Incubation of L5178Y murine lymphoma cells in vitro with 1,2-dithiole-3-thione (D3T) increased the level of DT-diaphorase activity in these cells 22-fold. "
05/01/2008 - "A variety of synthetic 1,2-dithiole-3-thione derivatives also inhibited S6K1 activity and insulin resistance induced by hyperosmotic stress in HepG2 cells. "
01/01/2009 - "Oltipraz and other novel 1,2-dithiole-3-thione congeners have the capability to prevent insulin resistance via AMP-activated protein kinase (AMPK) activation. "
|5.||Hepatocellular Carcinoma (Hepatoma)
06/01/1986 - "The parent 1,2-dithiol-3-thione nucleus and a series of six substituted analogs all induced NAD(P)H: quinone reductase (EC 18.104.22.168) activity and elevated glutathione levels in Hepa 1c1c7 murine hepatoma cells in culture thereby enhancing detoxification potential. "
06/01/1986 - "1,2-Dithiol-3-thione analogs: effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells."
09/12/1995 - "When these three constructs were compared in Hep G2 (human) and Hepa 1c1c7 (murine) hepatoma cells, the wild-type sequence was highly activated by diverse inducers, including tert-butylhydroquinone, Michael reaction acceptors, 1,2-dithiole-3-thione, sulforaphane,2,3-dimercapto-1-propanol, HgCl2, sodium arsenite, and phenylarsine oxide. "
|2.||Aflatoxin B1 (Aflatoxin B)
|3.||Biological Markers (Surrogate Marker)
|5.||Butylated Hydroxyanisole (BHA)
|6.||NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)
|8.||AMP-Activated Protein Kinases