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11,17- dihydroxy- 6- methyl- 17- (1- propynyl)androsta- 1,4,6- triene- 3- one

glucocorticoid receptor agonist; RN given refers to (11beta,17beta)-isomer

Also Known As:

RU 28362; RU 362; RU-28362; RU-362

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Androstanes: 11
      - Androstanols
        11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one: 4

Experts

1.	Marissal-Arvy, N: 1 article (06/2000)
2.	Mormède, P: 1 article (06/2000)
3.	Ribot, E: 1 article (06/2000)
4.	Sarrieau, A: 1 article (06/2000)

Related Diseases

1.	Weight Loss (Weight Reduction) 06/01/2000 - "Alternatively, RU 28362 treatment induced greater weight loss, decrease in food intake, anxiolysis, thymus involution, and decrease in plasma transcortin concentration and pituitary corticosteroid receptor densities in Brown Norway rats than in F344 rats, which is consistent with greater efficiency of GR mechanisms in Brown Norway rats than in F344 rats. "
2.	Hyperaldosteronism (Conn Syndrome) 03/01/1989 - "3. Hyperaldosteronism secondary to dietary Na+ depletion for 10-14 days, dexamethasone (600 micrograms 100 g-1 day-1 for 3 days), and RU 28362 (600 micrograms 100 g-1 day-1 for 3 days) induced amiloride-sensitive electrogenic Na+ transport, with the potency of aldosterone greater than dexamethasone greater than RU 28362. "
3.	Body Weight (Weight, Body) 05/01/1996 - "The aldosterone-induced increase in body weight gain and carcass water were attenuated by RU-28362 (type II receptor agonist) infusion, suggesting that type II receptor stimulation can antagonize the effect of type I receptor stimulation. "
4.	Adenocarcinoma 05/01/1997 - "The relative abilities of a potent glucocorticoid receptor (GR) agonist (RU 28362), a weak GR agonist (aldosterone) and a potent GR antagonist (RU 38486) to promote in vivo activation/transformation and subsequent down-regulation of GR mRNA and protein levels were compared using the PROb rat colonic adenocarcinoma cell line. "

Related Drugs and Biologics

1.	Aldosterone
2.	Mifepristone (RU 486)
3.	Transcortin
4.	Messenger RNA (mRNA)
5.	Steroid Receptors (Steroid Receptor)
6.	Glucocorticoid Receptors (Glucocorticoid Receptor)
7.	Proteins (Proteins, Gene)
8.	Dexamethasone (Maxidex)
9.	Amiloride (Midamor)