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2- hydroxy- 3,7,8- trichlorodibenzo- 4- dioxin

mammalian metabolite of 2,3,7,8-TCDD; structure in first source

Also Known As:

2-hydroxy-3,7,8-trichloroDD; 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Dioxins and Dioxin-like Compounds: 5
  - Dioxins: 1199
    - Polychlorinated Dibenzodioxins: 2278
      - 2-hydroxy-3,7,8-trichlorodibenzo-4-dioxin: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Polychlorinated Dibenzodioxins: 2278
      - 2-hydroxy-3,7,8-trichlorodibenzo-4-dioxin: 1

Related Diseases

1.	Body Weight (Weight, Body) 10/01/1986 - "The compounds were individually administered to immature male Wistar rats and their effects on body weight loss, thymic atrophy, liver and spleen weights and their activities as inducers of hepatic microsomal benzo[a]pyrene hydroxylase, 4-chlorobiphenyl hydroxylase and ethoxyresorufin O-deethylase were determined using dose levels of 100, 1000 and 5000 micrograms/kg. The 2 metabolites did not affect organ or body weights after 14 days of exposure and only 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin was active as an inducer of the microsomal monooxygenases at dose levels of 1000 and 5000 micrograms/kg. A comparison of the relative enzyme induction activities of 2,3,7,8-TCDD and 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin indicates that the former compound was greater than 3 orders of magnitude more active than the metabolite."
2.	Atrophy 10/01/1986 - "The compounds were individually administered to immature male Wistar rats and their effects on body weight loss, thymic atrophy, liver and spleen weights and their activities as inducers of hepatic microsomal benzo[a]pyrene hydroxylase, 4-chlorobiphenyl hydroxylase and ethoxyresorufin O-deethylase were determined using dose levels of 100, 1000 and 5000 micrograms/kg. The 2 metabolites did not affect organ or body weights after 14 days of exposure and only 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin was active as an inducer of the microsomal monooxygenases at dose levels of 1000 and 5000 micrograms/kg. A comparison of the relative enzyme induction activities of 2,3,7,8-TCDD and 2-hydroxy-3,7,8-trichlorodibenzo-p-dioxin indicates that the former compound was greater than 3 orders of magnitude more active than the metabolite."

Related Drugs and Biologics

1.	Cytochrome P-450 CYP1A1 (CYP1A1)
2.	Benzopyrene Hydroxylase
3.	Aryl Hydrocarbon Hydroxylases
4.	4-chlorobiphenyl hydroxylase