ajoene

11/23/2022 - "The results of this study provide mechanistic insights into the character of the anti-cancer activity of the natural dietary compound ajoene."
03/01/2016 - "ROS-mediated induction of apoptosis contributes partially to the anti-tumorigenic property of ajoene observed, a phenomenon also confirmed by xenograft tumor study. "
04/01/2012 - "Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells."
07/01/2003 - "Taking together the results of the in vivo and in vitro studies, we conclude that ajoene can reduce BCC tumor size, mainly by inducing the mitochondria-dependent route of apoptosis."
11/23/2022 - "Pathway analysis elucidated that ajoene targets functional and signaling pathways that are implicated in cancer cell survival, specifically cellular processes, metabolism, and genetic information processing pathways. "

11/01/2000 - "Ajoene, an organosulfur compound originally isolated from garlic, has been shown to be effective in short-term treatment of tinea pedis. "
09/01/1996 - "The present report shows the efficacy of ajoene, a garlic-derived organic trisulphur, for short-term therapy of tinea pedis. "
09/01/1996 - "Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis."
09/01/1996 - "These results show that ajoene is an alternative, efficient and low-cost antimycotic drug for short-term therapy of tinea pedis. "
11/01/2000 - "Efficacy of ajoene in the treatment of tinea pedis: a double-blind and comparative study with terbinafine."

01/01/2016 - "The study investigated the in vitro, ex vivo and in vivo efficacy of ajoene and ciprofloxacin (CIP) alone and in combination against Pseudomonas aeruginosa biofilms and biofilm-associated murine acute pyelonephritis. "
01/01/2016 - "Exploiting the antivirulence efficacy of an ajoene-ciprofloxacin combination against Pseudomonas aeruginosa biofilm associated murine acute pyelonephritis."

11/10/2019 - "In the present study, we found that ajoene, a sulfur compound found in crushed garlic, exhibits protective effects against muscle atrophy. "
11/10/2019 - "In mature myotubes, Z-ajoene protected against muscle protein degradation induced by conditioned media from CT26 colon carcinoma cells, by suppressing expression of muscle specific E3 ligases and nuclear transcription factor kappa B (NF-κB) phosphorylation which contribute to muscle atrophy. "

06/01/2006 - "This study deals with a recently described antifungal property of ajoene, and its potential use in clinical trails to treat several fungal infections."
06/01/1999 - "These results and those obtained in previous studies confirm that ajoene is a new agent for the topic treatment of superficial mycoses, and for the first time show the therapeutic usefulness of an inhibitor of phospholipids biosynthesis in eukaryotes."