|1.||Apitz-Castro, Rafael: 5 articles (09/2009 - 07/2003)|
|2.||Parker, M Iqbal: 3 articles (04/2012 - 01/2010)|
|3.||Kaschula, Catherine H: 3 articles (04/2012 - 01/2010)|
|4.||Hunter, Roger: 3 articles (04/2012 - 01/2010)|
|5.||Ledezma, Eliades: 3 articles (04/2009 - 03/2004)|
|6.||Apitz-Castro, R: 3 articles (03/2008 - 11/2000)|
|7.||Li, Min: 3 articles (06/2007 - 04/2002)|
|8.||Yamada, Norihiko: 3 articles (04/2006 - 10/2002)|
|9.||Nishikawa, Tomoaki: 3 articles (04/2006 - 10/2002)|
|10.||Fujino, Tsuchiyoshi: 3 articles (04/2006 - 10/2002)|
04/01/2012 - "Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells."
01/01/2010 - "Structure-activity studies on ajoene and ajoene analogues have revealed that the Z-isomer is moderately more active than the E-isomer at inhibiting in vitro tumor cell growth, suggesting that specific protein interactions may be important. "
07/01/2003 - "Taking together the results of the in vivo and in vitro studies, we conclude that ajoene can reduce BCC tumor size, mainly by inducing the mitochondria-dependent route of apoptosis."
07/01/2014 - "A garlic-derived compound, Z-ajoene, has shown a range of biological activities, including anti-proliferative effects on several cancers. "
04/01/2012 - "A library of twelve such derivatives tested for their anti-proliferation activity against WHCO1 oesophageal cancer cells has identified a derivative containing p-methoxybenzyl (PMB)-substituted end groups that is twelve times more active than Z-ajoene, with an IC(50) of 2.1μM (Kaschula et al., 2011 ). "
|2.||Tinea Pedis (Athlete's Foot)
11/01/2000 - "Ajoene, an organosulfur compound originally isolated from garlic, has been shown to be effective in short-term treatment of tinea pedis. "
09/01/1996 - "The present report shows the efficacy of ajoene, a garlic-derived organic trisulphur, for short-term therapy of tinea pedis. "
09/01/1996 - "Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis."
09/01/1996 - "These results show that ajoene is an alternative, efficient and low-cost antimycotic drug for short-term therapy of tinea pedis. "
11/01/2000 - "Efficacy of ajoene in the treatment of tinea pedis: a double-blind and comparative study with terbinafine."
06/01/2006 - "This study deals with a recently described antifungal property of ajoene, and its potential use in clinical trails to treat several fungal infections."
09/30/2008 - "The natural compound ajoene (4,5,9- trithiadodeca-1,6,11-triene 9-oxide) is capable of controlling infection by Paracoccidioides brasiliensis in experimental models. "
06/01/2007 - "We further demonstrated a new activity of Z-ajoene against human cytomegalovirus spreading in vitro that was mediated by an increased number of apoptotic cells after infection. "
01/01/1997 - "Ajoene showed dose-dependent inhibition, with 50% cytotoxic concentration (CTC50%) and 50% effective inhibitory concentration (EIC50%) values of 1.88 microM and about 0.35 microM, respectively, when the test compound was added before or after HIV-1 infection and incubation carried out at 37 degrees C for 4 days. "
02/01/1994 - "A single ajoene dose of 50 mg/kg, on the day of infection, suppressed the development of parasitemia; there were no obvious acute toxic effects from the tested dose. "
08/01/1994 - "Our results indicate that administration of ajoene to heparinized animals, significantly prevents thrombus formation at local low blood shear rate. "
10/15/1992 - "Our results suggest that ajoene may be useful for the acute prevention of thrombus formation induced by vascular damage."
10/15/1992 - "Our results indicate that ajoene prevents thrombus formation both at low and high shear rate in citrated whole blood. "
10/15/1992 - "Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation."
07/01/2004 - "Several clinical trials and in vitro studies of ajoene have demonstrated its best-known anti-thrombosis, anti-microbial and cholesterol lowering activities. "
|5.||Melanoma (Melanoma, Malignant)
03/31/2004 - "In this study we evaluated the hypothesis that the antitumor activity of ajoene could be associated with its apoptosis-inducing effect, and with its ability to block the expression of the alpha(4)beta(1) integrin, in the murine melanoma B16F10 cells. "
04/01/2009 - "Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells."
03/31/2004 - "Apoptotic and anti-adhesion effect of ajoene, a garlic derived compound, on the murine melanoma B16F10 cells: possible role of caspase-3 and the alpha(4)beta(1) integrin."
08/08/2006 - "We found ajoene to inhibit tumor cell growth in vitro, but also to inhibit strongly metastasis to lung in the B16/BL6 melanoma tumor model in C57BL/6 mice. "
08/08/2006 - "Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice."
|1.||diallyl disulfide (diallyl disulphide)
|2.||S-allylcysteine (allyl cysteine)
|5.||amsonic acid (DAS)