|1.||Hypotension (Low Blood Pressure)
01/01/1988 - "5) NB-818 0.003-0.1 mg/kg intraduodenally (i.d.) also caused a longer lasting increase in VBF with a slower onset that was accompanied by moderate hypotension and was dose-dependent. "
01/01/1988 - "The results from the present study indicate that NB-818 predominantly increases rCBF with a concomitant moderate hypotension, and its action is greater than that of nicardipine or nimodipine."
01/01/1988 - "Thus, NB-818 predominantly increases VBF with concomitant moderate hypotension, and its action is of significantly slower onset and longer duration than that of nicardipine and nimodipine."
07/01/1991 - "In this experiment, NB-818 exhibited a protective effect on DND in the hippocampal CA1 subfield after transient forebrain ischemia, and its effect persisted for up to 4 weeks. "
07/01/1991 - "In addition, NB-818 (3 mg/kg) significantly inhibited DND at 1, 2 and 4 weeks after transient ischemia: the average NCD of the NB-818 and ischemic control groups were 80 +/- 9.4 (P less than 0.01) and 43 +/- 7.7 cells/mm, 92 +/- 13.7 (P less than 0.05) and 52 +/- 9.3 cells/mm, and 57 +/- 5.0 (P less than 0.01) and 43 +/- 12.4 cells/mm, respectively. "
07/01/1991 - "The effect of NB-818, a new dihydropyridine calcium entry blocker, on delayed neuronal death (DND) in the hippocampal CA1 subfield of gerbils after 5 minutes of forebrain ischemia induced by bilateral carotid artery occlusion was examined. "
|3.||Brain Edema (Cerebral Edema)