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LM 985
structure given in first source; RN given refers to parent cpd
Also Known As:
LM 985 hydrochloride; LM-985; LM985; NSC 293015; flavone acetic acid diethanolamine ester; oxo-4-phenyl-2,4,H-1-benzopyran-8-yl 2-diethylaminoethyl acetate HCl
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Chromones: 159
Flavonoids: 9773
LM 985: 6
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Chromones: 159
Flavonoids: 9773
LM 985: 6
Related Diseases
1.
Neoplasms (Cancer)
02/01/1993 - "
On the basis of this particular profile LM 985 was selected by the Cancer Research Campaign (CRC) UK for phase I clinical trial.
"
08/01/1987 - "
In conclusion, LM975 and LM985 do not appear to have a specific cytotoxicity for tumor cells.
"
06/01/1987 - "
Thirty-one adult patients with solid tumors received a total of 57 courses of LM985 given on days 1 and 8 every 4 weeks.
"
10/01/1986 - "
The MAC system shows a good correlation with human large bowel cancer and these preliminary observations with LM985 would suggest that it or its metabolite LM975 may have a value in the management of large bowel cancer.
"
06/01/1986 - "
LM975 is active in a variety of animal tumor models, but it does not have the cardiovascular side effects seen with LM985 (hypotension and bradycardia) in pithed or anesthetized rats.
"
2.
Colorectal Neoplasms (Colorectal Cancer)
06/01/1986 - "
One patient with colorectal carcinoma had stable disease after three courses of LM985; however, no other responses were seen.
"
3.
Leukemia
08/01/1987 - "
The antitumor effect of flavone acetic acid, LM975, and its diethylaminoethyl ester derivative, LM985, was studied in four human malignant cell lines [WiDr, a colon carcinoma; LICR (LON) HN-3, a tongue carcinoma; MCF7, a breast carcinoma; K-562, a leukemia] using a colorimetric assay based on the reduction of dimethylthiazol-2-yl-diphenyltetrazolium.
"
4.
Hypotension (Low Blood Pressure)
06/01/1986 - "
LM975 is active in a variety of animal tumor models, but it does not have the cardiovascular side effects seen with LM985 (hypotension and bradycardia) in pithed or anesthetized rats.
"
5.
Carcinoma (Carcinomatosis)
08/01/1987 - "
The antitumor effect of flavone acetic acid, LM975, and its diethylaminoethyl ester derivative, LM985, was studied in four human malignant cell lines [WiDr, a colon carcinoma; LICR (LON) HN-3, a tongue carcinoma; MCF7, a breast carcinoma; K-562, a leukemia] using a colorimetric assay based on the reduction of dimethylthiazol-2-yl-diphenyltetrazolium.
"
Related Drugs and Biologics
1.
flavone acetic acid
2.
Esters
3.
Antineoplastic Agents (Antineoplastics)
4.
2,2',2''-trichlorotriethylamine (HN 3)