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DNA ligase (ATP)

mammalian DNA ligase I is cytoplasmic & has high MW with lower Km for ATP than nuclear DNA ligase II; RefSeq NM_206937 (LIG4, human), NM_176953 (Lig4, mouse), NM_010715 (Lig1, mouse), NM_000234 (LIG1, human), NM_030855 (Lig1, rat); GenBank Z74913 (DNL4, S cerevisiae); do not confuse with LIG-1 protein, a leucine-rich repeats and immunoglobulin-like domains 1 protein
Also Known As:
CDC9 protein, S cerevisiae; DNA ligase I; DNA ligase I, rat; DNA ligase II; DNA ligase II, S cerevisiae; DNA ligase IV; DNA ligase IV homolog, S cerevisiae; DNA ligase IV, human; DNA ligase IV, mouse; DNL4 protein, S cerevisiae; LIG1 protein, human; LIG4 protein, S cerevisiae; LIG4 protein, human; Lig1 protein, mouse; Lig1 protein, rat; Lig4 protein, mouse; LigI protein, mouse; MMS8 protein, S cerevisiae; Sealase protein, human; ligase I, DNA, ATP-dependent protein, human; ligase I, DNA, ATP-dependent protein, mouse; ligase IV, DNA, ATP-dependent protein, human; ligase IV, DNA, ATP-dependent protein, mouse; mLigI protein, mouse; polydeoxyribonucleotide synthase (ATP)
Networked: 99 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Ketner, Gary: 3 articles (07/2012 - 07/2007)
2. Tomkinson, Alan E: 3 articles (01/2012 - 08/2008)
3. McKinnon, Peter J: 3 articles (06/2011 - 11/2002)
4. Jeggo, P A: 3 articles (07/2005 - 08/2001)
5. Sun, Daekyu: 3 articles (11/2002 - 04/2002)
6. Nguyen, Myhanh: 3 articles (11/2002 - 04/2002)
7. Urrabaz, Rheanna: 3 articles (11/2002 - 04/2002)
8. Jeggo, Penny A: 2 articles (10/2015 - 07/2011)
9. Ju, Limei: 2 articles (10/2015 - 07/2011)
10. Kotnis, Ashwin: 2 articles (06/2014 - 03/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Genetic Translocation (Chromosomal Translocation)
3. Head and Neck Neoplasms (Head and Neck Cancer)
4. Carcinoma (Carcinomatosis)
5. Ataxia Telangiectasia (Louis Bar Syndrome)

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
3. DNA Ligases (Ligases, DNA)
4. 1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)
5. Transforming Growth Factor beta (TGF-beta)
6. Cytidine
7. Cisplatin (Platino)
8. Chromatin
9. gemcitabine
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Radiotherapy