|1.||Ketner, Gary: 3 articles (07/2012 - 07/2007)|
|2.||Tomkinson, Alan E: 3 articles (01/2012 - 08/2008)|
|3.||McKinnon, Peter J: 3 articles (06/2011 - 11/2002)|
|4.||Jeggo, P A: 3 articles (07/2005 - 08/2001)|
|5.||Sun, Daekyu: 3 articles (11/2002 - 04/2002)|
|6.||Nguyen, Myhanh: 3 articles (11/2002 - 04/2002)|
|7.||Urrabaz, Rheanna: 3 articles (11/2002 - 04/2002)|
|8.||Jeggo, Penny A: 2 articles (10/2015 - 07/2011)|
|9.||Ju, Limei: 2 articles (10/2015 - 07/2011)|
|10.||Kotnis, Ashwin: 2 articles (06/2014 - 03/2009)|
09/01/2013 - "In the present study, the association of polymorphic forms of DNA repair gene, DNA ligase I (LIGI) was examined with the risk of cervical cancer in case of North Indian women. "
06/01/2014 - "Novel inhibitor of DNA ligase IV with a promising cancer therapeutic potential."
09/01/2013 - "Human DNA ligase i (ligi) gene and risk of cervical cancer in North Indian women."
09/01/2008 - "The known cellular substrates for degradation by E1b55K/E4orf6 are the Mre11/Rad50/Nbs1 DNA repair complex, the tumor suppressor p53, and DNA ligase IV. Here we show that the degradation of individual targets can occur independently of other substrates. "
04/01/2008 - "A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers."
|2.||Genetic Translocation (Chromosomal Translocation)
06/01/2011 - "The canonical NHEJ pathway, including DNA ligase IV (Lig4), suppresses genomic instability and chromosomal translocations, leading to the notion that a poorly defined, alternative NHEJ (alt-NHEJ) pathway generates these rearrangements. "
01/01/2013 - "In addition to microhomology-mediated end-joining events, recent studies in mammalian cells point toward the existence of a distinct and still ill defined alternative end-joining pathway that does not appear to rely on pre-existing microhomologies and may possibly involve DNA Ligase I. Whether dependent on microhomologies or not, alternative DNA end-joining mechanisms are likely to be highly mutagenic in vivo, being able to drive telomere fusion events and cancer-associated chromosomal translocations in mouse models. "
|3.||Head and Neck Neoplasms (Head and Neck Cancer)
02/01/2012 - "The aim of this study was to investigate the association between 10 SNPs in genes involved in cell cycle control and DNA repair (p21 C31A, p53 G72C, ATM G1853A, XRCC1 G399A, XRCC3 C241T, Ku80 A2790G, DNA Ligase IV C9T, DNA-PKcs A3434G, TGF-beta T10C, MDM2 promoter T309G) and the risk to develop head and neck cancer. "
|5.||Ataxia Telangiectasia (Louis Bar Syndrome)
10/01/2015 - "We used mice with a hypomorphic mutation in DNA ligase IV (Lig4(Y288C)), ataxia telangiectasia mutated (Atm(-/-)) and double mutant Atm(-/-)/Lig4(Y288C) mice. "
03/01/2013 - "Moreover, both the results of the γH2AX foci staining assay and the comet assay further revealed that ID1 negatively regulates DNA repair processes by downregulating the expression of genes such as DNA ligase IV (LIG4) and ataxia-telangiectasia-mutated. "
01/01/2007 - "Cellular radiosensitivity in the absence of clinical manifestations of Ataxia telangiectasia lead to the diagnosis of DNA ligase IV (LIG4) deficiency syndrome, confirmed by compound heterozygous mutations in the LIG4 gene. "
01/01/2006 - "Patients with defects in ataxia-telangiectasia mutated, nibrin, MRE11, Rad50, Artemis, DNA ligase IV and Cernunnos-XRCC4-like factor have been identified. "
08/01/2002 - "Patients with grade 3 reactions were tested for mutations in ataxia telangiectasia (AT), Nijmegen Breakage Syndrome (NBS), MRE11, RAD50 and DNA ligase IV genes by means of polymerase chain reaction-single-strand conformation polymorphism and sequencing analysis. "
|1.||DNA (Deoxyribonucleic Acid)
|2.||lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
|3.||DNA Ligases (Ligases, DNA)
|4.||1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)
|5.||Transforming Growth Factor beta (TGF-beta)
|10.||Proteins (Proteins, Gene)