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nocloprost
phalloidin transport inhibitor
Networked:
12
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Lipids: 114793
Fatty Acids: 27405
Unsaturated Fatty Acids: 8236
Eicosanoids: 3262
Prostaglandins: 17100
Synthetic Prostaglandins: 823
Synthetic Prostaglandins F: 2
nocloprost: 12
Biological Factors: 2472
Inflammation Mediators: 1113
Synthetic Prostaglandins: 823
Synthetic Prostaglandins F: 2
nocloprost: 12
Autacoids: 276
Eicosanoids: 3262
Prostaglandins: 17100
Synthetic Prostaglandins: 823
Synthetic Prostaglandins F: 2
nocloprost: 12
Related Diseases
1.
Ulcer
04/03/1991 - "
We conclude that nocloprost is a locally active PGE2 analog with high cytoprotective and ulcer-healing efficacy.
"
04/03/1991 - "
Nocloprost (9 beta-chloro-16,16-dimethyl prostaglandin E2 (PGE2)) was examined for gastroprotective and ulcer-healing activity and compared to 16,16-dimethyl PGE2 (dmPGE) in rats.
"
04/03/1991 - "
Nocloprost, a unique prostaglandin E2 analog with local gastroprotective and ulcer-healing activity.
"
01/01/1991 - "
Nocloprost, a unique PGE2 analog, with local gastroprotective and ulcer healing activity.
"
10/01/1997 - "
Similarly, patients treated with nocloprost had significantly higher EGF output in saliva and higher EGF concentration in plasma throughout the anti-ulcer therapy.
"
2.
Stomach Ulcer (Gastric Ulcer)
10/01/1997 - "
The gastric ulcer healing rate after 4 weeks was significantly higher in patients treated with nocloprost than in those treated with ranitidine (63% versus 39%, respectively).
"
01/01/1997 - "
The 24 patients with gastric ulcer were treated ranitidine (2 x 150 mg daily) or nocloprost (2 x 200 micrograms daily).
"
01/01/1997 - "
Effects of ranitidine or nocloprost on the selected gastric juice components in the patients with the gastric ulcer.
"
07/01/1993 - "
Nocloprost, a 9 beta-chloro-16,16-dimethyl derivative of prostaglandin E2 (PGE2), belongs to the gastric cytoprotective agents that are used in the therapy of gastric ulcer.
"
10/01/1997 - "
In this double-blind, randomized, prospective study 40 patients with gastric ulcer were treated with nocloprost, a stable prostaglandin E2 derivative, or with ranitidine.
"
3.
Body Weight (Weight, Body)
04/01/1993 - "
Pharmacokinetic interactions of 400 micrograms nocloprost with 15 mg/kg antipyrine and 500 mg sulfamethazine (all given p.o.) were studied with a controlled, single-blind crossover trial in 16 healthy male volunteers (age 22-25 years, body weight 63-94 kg, body height 175-187 cm) in order to measure potential interferences with oxidative and conjugative drug metabolism.
"
08/01/1993 - "
Pharmacokinetic interactions of cytoprotective prostaglandin E2 analog nocloprost clathrate with theophylline and diclofenac were studied in two placebo controlled, single-blind studies with parallel groups (n = 8) in healthy male volunteers (age 20-32 years, body weight 63-95 kg, body height 169-193 cm, Broca index 0.81-1.18).
"
4.
Intracranial Vasospasm
01/01/1989 - "
Cerebral vasospasm: resolution by iloprost, nocloprost and UK 38 485.
"
5.
Peptic Ulcer (Peptic Ulcers)
11/01/1991 - "
We conclude that nocloprost does not affect gastric acid secretion or intraluminal pH when applied at a dose (50-100 micrograms) that is gastroprotective and that is proposed for peptic ulcer therapy.
"
Related Drugs and Biologics
1.
Ranitidine (Zantac)
2.
Epidermal Growth Factor (EGF)
3.
Sulfamethazine (Sulfadimidine)
4.
Antipyrine (Phenazone)
5.
Dinoprostone (PGE2)
6.
Iloprost (Ventavis)
7.
Theophylline (Theon)
8.
Prostaglandins
9.
Irritants (Vesicants)
10.
Indomethacin (Indometacin)
Related Therapies and Procedures
1.
Therapeutics