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Rose Bengal B
structure given in first source
Also Known As:
Food Red 105; Rose Bengal B dipotassium salt, 131I-labeled cpd; Rose Bengal B disodium salt; Rose Bengal B disodium salt, 131I-labeled cpd; Rose Bengal B, dipotassium salt
Networked:
5
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Spiro Compounds: 2
Fluoresceins: 2
Rose Bengal: 1083
Rose Bengal B: 5
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Xanthenes: 65
Fluoresceins: 2
Rose Bengal: 1083
Rose Bengal B: 5
Polycyclic Compounds: 6
Spiro Compounds: 2
Fluoresceins: 2
Rose Bengal: 1083
Rose Bengal B: 5
Related Diseases
1.
Pain (Aches)
06/01/1996 - "
Improvement with therapy was defined as: (a) > or = 20% improvement in variables of tear flow (Schirmer's test I) or corneal integrity (rose Bengal): (b) > or = 20% salivary function (flow rate); and (c) improvement in at least two of the following measures: physicians assessment of global disease activity by > or = 20%, patient assessment of improvement in pain or fatigue by > or = 20%, and ESR improved by > or = 20 mm/hr. In a retrospective study of SS patients who completed the trial, a significant improvement was noted in ocular symptoms (pain and dryness) in patients (55 and 57%) and improved corneal integrity (rose Bengal straining) in 53% of patients.
"
2.
Fatigue
06/01/1996 - "
Improvement with therapy was defined as: (a) > or = 20% improvement in variables of tear flow (Schirmer's test I) or corneal integrity (rose Bengal): (b) > or = 20% salivary function (flow rate); and (c) improvement in at least two of the following measures: physicians assessment of global disease activity by > or = 20%, patient assessment of improvement in pain or fatigue by > or = 20%, and ESR improved by > or = 20 mm/hr. In a retrospective study of SS patients who completed the trial, a significant improvement was noted in ocular symptoms (pain and dryness) in patients (55 and 57%) and improved corneal integrity (rose Bengal straining) in 53% of patients.
"
3.
Neoplasms (Cancer)
05/05/1995 - "
FD&C Red No. 105 (Rose Bengal B) neutralizes the thyroid tumor promoting effect of iodine-deficient diet in rats.
"
03/01/1988 - "
The promoting effects of food dyes, erythrosine (Red 3) and rose bengal B (Red 105), on thyroid tumors in partially thyroidectomized N-bis(2-hydroxypropyl)-nitrosamine-treated rats.
"
03/01/1988 - "
The effects of erythrosine (Red 3), rose bengal B (Red 105) and thyroidectomy on the development of thyroid tumor were examined in male Wistar rats treated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
"
07/01/1986 - "
Induction of thyroid tumors in (C57BL/6N x C3H/N)F1 mice by oral administration of 9-3',4',5',6'-tetrachloro-o-carboxy phenyl-6-hydroxy-2,4,5,7-tetraiodo-3-isoxanthone sodium (Food Red 105, rose bengal B).
"
4.
Carcinogenesis
01/01/1990 - "
To evaluate the mechanism of the promoting effect of goitrogens on thyroid tumorigenesis, well-known goitrogens having different pharmacologic action, i.e., thiourea, phenobarbital sodium (PB), potassium thiocyanate (KSCN), and 3,4,5,6-tetrachloro-2',4',5',7'-tetraiodo-fluorescein sodium salt (Rose Bengal B, FD&C Red No. 105) (FR105) were administered to the DHPN-initiated and non-initiated F344 male rats in the drinking water for 25 weeks.
"
Related Drugs and Biologics
1.
Rose Bengal
2.
Sodium
3.
Rose Bengal B
4.
diisopropanolnitrosamine
5.
Drinking Water
6.
Pharmacologic Actions
7.
Antithyroid Agents (Antithyroid Drugs)
8.
Thiourea
9.
Salts
10.
Phenobarbital (Luminal)
Related Therapies and Procedures
1.
Therapeutics
2.
Thyroidectomy
3.
Oral Administration