Rose Bengal B

structure given in first source

Also Known As:

Food Red 105; Rose Bengal B dipotassium salt, 131I-labeled cpd; Rose Bengal B disodium salt; Rose Bengal B disodium salt, 131I-labeled cpd; Rose Bengal B, dipotassium salt

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - Fluoresceins: 2
        Rose Bengal: 1083
        Rose Bengal B: 5
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Fluoresceins: 2
        Rose Bengal: 1083
        Rose Bengal B: 5
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - Fluoresceins: 2
    - Rose Bengal: 1083
      - Rose Bengal B: 5

Related Diseases

1.	Pain (Aches) 06/01/1996 - "Improvement with therapy was defined as: (a) > or = 20% improvement in variables of tear flow (Schirmer's test I) or corneal integrity (rose Bengal): (b) > or = 20% salivary function (flow rate); and (c) improvement in at least two of the following measures: physicians assessment of global disease activity by > or = 20%, patient assessment of improvement in pain or fatigue by > or = 20%, and ESR improved by > or = 20 mm/hr. In a retrospective study of SS patients who completed the trial, a significant improvement was noted in ocular symptoms (pain and dryness) in patients (55 and 57%) and improved corneal integrity (rose Bengal straining) in 53% of patients. "
2.	Fatigue 06/01/1996 - "Improvement with therapy was defined as: (a) > or = 20% improvement in variables of tear flow (Schirmer's test I) or corneal integrity (rose Bengal): (b) > or = 20% salivary function (flow rate); and (c) improvement in at least two of the following measures: physicians assessment of global disease activity by > or = 20%, patient assessment of improvement in pain or fatigue by > or = 20%, and ESR improved by > or = 20 mm/hr. In a retrospective study of SS patients who completed the trial, a significant improvement was noted in ocular symptoms (pain and dryness) in patients (55 and 57%) and improved corneal integrity (rose Bengal straining) in 53% of patients. "
3.	Neoplasms (Cancer) 05/05/1995 - "FD&C Red No. 105 (Rose Bengal B) neutralizes the thyroid tumor promoting effect of iodine-deficient diet in rats." 03/01/1988 - "The promoting effects of food dyes, erythrosine (Red 3) and rose bengal B (Red 105), on thyroid tumors in partially thyroidectomized N-bis(2-hydroxypropyl)-nitrosamine-treated rats." 03/01/1988 - "The effects of erythrosine (Red 3), rose bengal B (Red 105) and thyroidectomy on the development of thyroid tumor were examined in male Wistar rats treated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). " 07/01/1986 - "Induction of thyroid tumors in (C57BL/6N x C3H/N)F1 mice by oral administration of 9-3',4',5',6'-tetrachloro-o-carboxy phenyl-6-hydroxy-2,4,5,7-tetraiodo-3-isoxanthone sodium (Food Red 105, rose bengal B)."
4.	Carcinogenesis 01/01/1990 - "To evaluate the mechanism of the promoting effect of goitrogens on thyroid tumorigenesis, well-known goitrogens having different pharmacologic action, i.e., thiourea, phenobarbital sodium (PB), potassium thiocyanate (KSCN), and 3,4,5,6-tetrachloro-2',4',5',7'-tetraiodo-fluorescein sodium salt (Rose Bengal B, FD&C Red No. 105) (FR105) were administered to the DHPN-initiated and non-initiated F344 male rats in the drinking water for 25 weeks. "

Related Drugs and Biologics

1.	Rose Bengal
2.	Sodium
3.	Rose Bengal B
4.	diisopropanolnitrosamine
5.	Drinking Water
6.	Pharmacologic Actions
7.	Antithyroid Agents (Antithyroid Drugs)
8.	Thiourea
9.	Salts
10.	Phenobarbital (Luminal)

Related Therapies and Procedures

1.	Therapeutics
2.	Thyroidectomy
3.	Oral Administration