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1,2-diacetylbenzene

Also Known As:

ortho-diacetylbenzene

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Acetophenones: 16
    - 1,2-diacetylbenzene: 9

Experts

1.	Kim, Min-Sun: 3 articles (10/2022 - 01/2008)
2.	Hoang, Ngoc Hong Minh: 1 article (10/2022)
3.	Jo, Won Hee: 1 article (10/2022)
4.	Nguyen, Hai Duc: 1 article (10/2022)
5.	Kang, Sin-Woo: 1 article (09/2017)
6.	Kim, Sung Jin: 1 article (09/2017)
7.	Boucard, Stéphane: 1 article (03/2014)
8.	Gagnaire, François: 1 article (03/2014)
9.	Couchi, E: 1 article (07/2012)
10.	Iordanov, M: 1 article (07/2012)

Related Diseases

1.	Memory Disorders (Memory Loss) 12/01/2022 - "In silico identification of the potential molecular mechanisms involved in protective effects of prolactin on motor and memory deficits induced by 1,2-Diacetylbenzene in young and old rats."
2.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 07/01/2012 - "We use 1,2-diacetylbenzene (1,2-DAB) to probe molecular mechanisms of proximal giant neurofilamentous axonopathy (PGNA), a pathological hallmark of amyotrophic lateral sclerosis. " 04/01/2005 - "The aromatic gamma-diketone 1,2-diacetylbenzene (1,2-DAB), the putative active metabolite of the organic solvent 1,2-diethylbenzene, forms blue-colored polymeric protein adducts and induces the formation of amyotrophic lateral sclerosis (ALS)-like giant, intraspinal neurofilamentous axonal swellings in Sprague Dawley rats. "
3.	Neuroinflammatory Diseases 08/01/2023 - "Protective effect of Prolactin releasing peptide against 1,2-diacetylbenzene -induced neuroinflammation." 10/01/2022 - "We aimed to evaluate the effects of 1,2-diacetylbenzene (DAB) and curcumin on neuroinflammation induced by DAB via triggering receptor expressed on myeloid cells 1 (TREM-1), Toll-like receptor 4 (TLR4), and NLR family pyrin domain containing 3 (NLP3)/calcium-dependent activator protein for secretion 1 (CAPS1)/interleukin 1 beta (IL1B) pathways; tau hyperphosphorylation; reactive oxygen species (ROS); and advanced glycation end-product (AGE) in microglia cells; and explore the molecular mechanisms involved in the key genes induced by DAB and targeted by curcumin in silico analysis. "
4.	Cognitive Dysfunction 02/01/2023 - "Converging evidence indicates the link between 1,2-diacetylbenzene (DAB), prolactin (PRL), risperidone, and cognitive impairment. "
5.	Peripheral Nervous System Diseases (PNS Diseases) 09/05/2017 - "Previously, the authors reported 1,2-diacetylbenzene (DAB; a neurotoxic metabolite of 1,2-diethylbenzene) causes central and peripheral neuropathies that lead to motor neuronal deficits. "

Related Drugs and Biologics

1.	Prolactin
2.	1,2-diethylbenzene
3.	Prolactin-Releasing Hormone (Prolactin Releasing Hormone)
4.	Interleukin-1beta (Interleukin 1 beta)
5.	Toll-Like Receptor 4
6.	Risperidone (Risperdal Consta)
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Advanced Glycation End Products
9.	Molecular Probes (Molecular Probe)
10.	Solvents