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molecular chaperone GRP78

found in intracellular mu-chains from pre-B-derived cell lines as well as variant nonsecreting myelomas; may have ATPase activity; BiP molecular chaperone preferentially stimulates proliferation of synovial T cells in patients with rheumatoid arthritis; MW 78 kDa; see also KAR2 gene product; overexpression is associated with adriamycin resistance; RefSeq NM_022310 (mouse)
Also Known As:
BiP molecular chaperone; BiP, Ig heavy chain binding protein; BiP670 protein, human; Bip protein, mouse; Bip-binding protein, Ig heavy chain; GRP78 protein, human; Grp78 protein, mouse; HSPA5 protein, human; Hspa5 protein, mouse; Ig heavy chain binding protein; Ig-HC-carrier protein; glucose regulated protein 78 kDa; glucose-regulated protein, 78kDa, human; heat shock 70kD protein 5 (glucose-regulated protein), mouse; heat shock 70kDa protein 5, human; heat-shock protein 5; immunoglobulin heavy chain-binding protein; molecular chaperone BiP
Networked: 41 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Park, Hae-Ryong: 3 articles (10/2009 - 04/2006)
2. Imaizumi, Kazunori: 2 articles (03/2010 - 01/2009)
3. Hara, Hideaki: 2 articles (03/2010 - 01/2009)
4. Saito, Atsushi: 2 articles (03/2010 - 01/2009)
5. Kudo, Takashi: 2 articles (03/2010 - 01/2009)
6. Cha, Mi-Ran: 2 articles (10/2009 - 01/2007)
7. Hara, H: 2 articles (05/2008 - 01/2008)
8. Shimazawa, M: 2 articles (05/2008 - 01/2008)
9. Imaizumi, K: 2 articles (05/2008 - 01/2008)
10. Oida, Y: 2 articles (05/2008 - 01/2008)

Related Diseases

1. Neoplasms (Cancer)
2. Weight Loss (Weight Reduction)
3. Multiple Myeloma
4. Shock
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Glucose (Dextrose)
2. Immunoglobulins (Immunoglobulin)
3. N-methylsuccinimide
4. bortezomib (Velcade)
5. Proteins (Proteins, Gene)
6. Protein Disulfide-Isomerases
7. Tunicamycin
8. Messenger RNA (mRNA)
9. CCAAT-Enhancer-Binding Proteins
10. HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)