|1.||Park, Hae-Ryong: 3 articles (10/2009 - 04/2006)|
|2.||Imaizumi, Kazunori: 2 articles (03/2010 - 01/2009)|
|3.||Hara, Hideaki: 2 articles (03/2010 - 01/2009)|
|4.||Saito, Atsushi: 2 articles (03/2010 - 01/2009)|
|5.||Kudo, Takashi: 2 articles (03/2010 - 01/2009)|
|6.||Cha, Mi-Ran: 2 articles (10/2009 - 01/2007)|
|7.||Hara, H: 2 articles (05/2008 - 01/2008)|
|8.||Shimazawa, M: 2 articles (05/2008 - 01/2008)|
|9.||Imaizumi, K: 2 articles (05/2008 - 01/2008)|
|10.||Oida, Y: 2 articles (05/2008 - 01/2008)|
05/01/2014 - "Glucose-regulated protein 78 kDa (GRP78/Bip), which has a role in cancer development, is one of the androgen response genes in prostate cell lines. "
01/01/2012 - "The molecular chaperone GRP78/BiP is a key regulator of protein folding in the endoplasmic reticulum, and it plays a pivotal role in cancer cell survival and chemoresistance. "
09/01/2011 - "Upregulation of the molecular chaperone BiP and the cell stress marker ATF3 indicated induction of the unfolded protein response (UPR) as the main cause of apoptosis induced by these drugs in cervical cancer cells. "
10/01/2009 - "The UPR is a stress-signaling pathway present in tumor cells that is associated with molecular chaperone GRP78. "
10/01/2009 - "The use of ion mobility separation coupled with MALDI-MSI improved the selectivity and specificity of the method and, hence, enabled both the localization and in situ identification of glucose regulated protein 78 kDa (Grp78), a tumor biomarker, within pancreatic tumor tissue sections. "
|2.||Weight Loss (Weight Reduction)
10/09/2014 - "Genetic overexpression of the chaperone GRP78/BiP (glucose-regulated protein 78 kDa/binding immunoglobulin protein) in the ventromedial nucleus of the hypothalamus (VMH) abolishes ceramide action by reducing hypothalamic ER stress and increasing BAT thermogenesis, which leads to weight loss and improved glucose homeostasis. "
02/20/2015 - "Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma."
02/01/2009 - "This study was aimed to explore the effect of bortezomib on the apoptosis and expression of the molecular chaperone BiP in human multiple myeloma cell line NCI-H929 (H929). "
09/01/1990 - "At 39 degrees C, newly synthesized G failed to fold correctly according to several criteria: intrachain disulfide bonds were incomplete; the B2 epitope was absent; and the protein was associated with immunoglobulin heavy chain binding protein (BiP), a heat shock-related, ER protein. "
08/01/1989 - "At least one cellular mRNA, encoding a heat shock-like protein, glucose-regulated protein 78/immunoglobulin heavy-chain binding protein, has been discovered to be translated at an increased rate in poliovirus-infected cells at a time when the translation of other cellular mRNAs is inhibited. "
08/01/2002 - "Cyclopentenone PGs also induce the expression of various stress genes, such as heat shock proteins (HSPs), the immunoglobulin heavy chain binding protein (BiP) and protein disulfide isomerase by acting through heat shock element or unfolded protein response element. "
12/01/2008 - "These are metabolic enzymes phosphoglycerate kinase 2, hexokinase 1, and glucose phosphate isomerase; proteins involved in sperm-egg fusion; angiotensin-converting enzyme, sperm adhesion molecule, and chaperones; heat shock 70-kDa protein 5 (glucose-regulated protein 78 kDa; and heat shock 70-kDa protein 1-like. "
|5.||Breast Neoplasms (Breast Cancer)
11/15/2014 - "Elevated expression of heat shock protein 5 (HSPA5) promotes drug resistance and metastasis and is a marker of poor prognosis in breast cancer patients. "
11/01/2009 - "Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70."
01/01/2013 - "Published microarray databases of breast cancer tissues and breast carcinoma cell lines were analyzed for PrP mRNA and ER stress marker immunoglobulin heavy chain binding protein (BiP) levels. "
|5.||Proteins (Proteins, Gene)
|8.||Messenger RNA (mRNA)
|10.||HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)