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21-deacetyldeflazacort
RN given refers to (11beta,16beta)-isomer
Also Known As:
21-deacetyldeflazacort, (11beta,16beta)-isomer, 2'-(14)C-labeled; 21-desacetyl-deflazacort; 21-hydroxy-DF; 21-hydroxy-deflazacort; 21-hydroxydeflazacort; L 6485; L-6485
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Pregnanes: 9
Pregnenes: 1
Pregnenediones
21-deacetyldeflazacort: 1
Related Diseases
1.
Hypersensitivity (Allergy)
02/01/1994 - "
Acute effects of deflazacort and its metabolite 21-desacetyl-deflazacort on allergic reactions.
"
02/01/1994 - "
Delayed type hypersensitivity in mice was also inhibited by deflazacort and 21-desacetyl-deflazacort, but prednisolone, at the doses used in the present study, had little effect on this immune response.
"
02/01/1994 - "
The acute effects of deflazacort (MDL 458, CAS 14484-47-0) and its metabolite, 21-desacetyl-deflazacort, on allergic reactions in animal models were investigated and compared with those of prednisolone.
"
2.
Arthus Reaction
02/01/1994 - "
The inhibitory effects of deflazacort on the passive cutaneous anaphylaxis, the reversed cutaneous anaphylaxis and the Arthus reaction were similar to those of 21-desacetyl-deflazacort and were stronger than those of prednisolone.
"
3.
Anaphylaxis (Anaphylactic Shock)
02/01/1994 - "
The inhibitory effects of deflazacort on the passive cutaneous anaphylaxis, the reversed cutaneous anaphylaxis and the Arthus reaction were similar to those of 21-desacetyl-deflazacort and were stronger than those of prednisolone.
"
02/01/1994 - "
Deflazacort, 21-desacetyl-deflazacort and prednisolone all inhibited 48-h homologous passive cutaneous anaphylaxis in rats, but had no significant effects on active systemic anaphylaxis in mice, on the Schultz-Dale reaction in the isolated guinea-pig trachea or on compound 48/80-induced histamine release in rat peritoneal mast cells.
"
Related Drugs and Biologics
1.
Prednisolone (Predate)
2.
deflazacort
3.
p-Methoxy-N-methylphenethylamine