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WR 151327

structure given in first source

Also Known As:

WR-151327; methylaminopropylaminopropylthiophosphorate; 1-Propanethiol, 3-((3-(methylamino)propyl)amino)-, dihydrogen phosphate (ester)

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organothiophosphorus Compounds
    - WR 151327: 4
- Sulfur Compounds: 278
  - Organothiophosphorus Compounds
    - WR 151327: 4

Experts

1.	Elliott, T B: 1 article (02/2000)
2.	Harding, R A: 1 article (02/2000)
3.	Inal, C E: 1 article (02/2000)
4.	Jackson, W E: 1 article (02/2000)
5.	Landauer, M R: 1 article (02/2000)
6.	Ledney, G D: 1 article (02/2000)

Related Diseases

1.	Bacterial Infections (Bacterial Infection) 02/01/2000 - "To determine the efficacy of WR-151327 (WR) [S-3-(3-methylaminopropylamino) propylphosphorothioic acid; (CH3-HN-(CH2)3-NH-(CH2)3-S-PO3H2)] in increasing resistance to bacterial infection after a sublethal dose of gamma-photons or mixed-field neutrons plus gamma-photons. "
2.	Carcinogenesis 01/01/1992 - "Two thiophosphoroate compounds WR-2721 and WR-151327 were assessed for their ability to modify the deleterious effects (life shortening and carcinogenesis) of fission-spectrum neutrons (kerma-weighted mean energy of 0.85 MeV) or gamma rays on B6CF1 hybrid mice. "
3.	Rhabdomyosarcoma 06/01/1994 - "In addition, WR-151327 suppressed HIV-LTR-CAT activity in transfected human rhabdomyosarcoma cells (RD). "
4.	Infections 02/01/2000 - "WR-151327 increases resistance to Klebsiella pneumoniae infection in mixed-field- and gamma-photon-irradiated mice."
5.	Body Weight (Weight, Body) 05/01/1992 - "The lowest dose of orally administered drug permitting probit analysis of data was 450 mg per kg. The calculated radioprotective dose reduction factors (DRF) at 450 mg per kg and 900 mg per kg of body weight (BW) WR-151327 were 1.2 and 1.3, respectfully. "

Related Drugs and Biologics

1.	Acids
2.	Amifostine (Ethyol)

Related Therapies and Procedures

1.	Drug Tapering