HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
5-(4-acetamidophenyl)pyrazin-2(1H)-one
structure given in first source
Also Known As:
SK&F 94120; SK&F-94120; SKF 94120
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrazines: 150
5-(4-acetamidophenyl)pyrazin-2(1H)-one: 4
Related Diseases
1.
Heart Failure
06/01/1987 - "
The actions of SK&F 94120, a selective phosphodiesterase (PDE III) inhibitor, have been characterised on human ventricular myocardium obtained from heart failure patients.
"
08/01/1993 - "
This potentiation, however, did not completely restore the response to levels seen in control myocytes.7. The extent of potentiation of the maximum isoprenaline response by maximum inotropic concentrations of either IBMX or CPT cyclic AMP, was no greater than that by threshold concentrations of IBMX, in myocytes isolated from noradrenaline-treated guinea-pig hearts.8. In cardiac myocytes isolated from the explanted hearts of 16 patients with heart failure, threshold concentrations of IBMX and SK&F 94120 decreased the isoprenaline EC50 by a factor of four and six,respectively, but potentiation of the maximum isoprenaline response occurred only with SK&F 94120.The attenuated isoprenaline response was increased from 60.3 +/- 4.5% to 74.3 +/- 4.2% as a % maximum calcium (P<0.05, n = 6), but remained substantially lower than the 116 +/- 7% (P<0.001, n = 6) seen in myocytes isolated from non-failing hearts.9. We conclude that the reduced maximum contraction amplitude with isoprenaline in cardiac myocytes from either patients in end-stage failure, or noradrenaline-treated guinea-pigs, is partly but not solely due to insufficient cyclic AMP levels, since inhibition of cyclic AMP degradation does not result incomplete reversal of the beta-adrenoceptor desensitization.
"
2.
Cardiotoxicity
05/01/1986 - "
The cardiotoxicity and haemodynamic changes induced by IV administration of high doses of SK&F 94120, a novel positive inotrope/vasodilator, were studied in the dog.
"
05/01/1986 - "
Cardiotoxicity of a new inotrope/vasodilator drug (SK&F 94120) in the dog.
"
3.
Necrosis
08/01/1988 - "
In rats treated with isoprenaline and SK&F 94120 at doses producing myocardial necrosis, only the LD1 isoenzymes showed any significant change but only within the first 24 h of treatment.
"
Related Drugs and Biologics
1.
Isoproterenol (Isoprenaline)
2.
1-Methyl-3-isobutylxanthine (1 Methyl 3 isobutylxanthine)
3.
Vasodilator Agents (Vasodilators)
4.
Adrenergic Receptors (Adrenergic Receptor)
5.
Phosphoric Diester Hydrolases (Phosphodiesterases)
6.
Norepinephrine (Noradrenaline)
7.
Isoenzymes
8.
Calcium
9.
Cyclic AMP (AMP, Cyclic)
10.
A-factor (Streptomyces)