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Description: isolated from the leaves of Azadirachta indica var. Siamensis; structure given in first source
Also Known As:| 1. | Shock
02/01/1986
- "LD50 values of higher than 600 mg/kg body wt. The possible cause of death induced by nimbic acid may be similar to that of nimbolide given i.v. and this is a sudden hypotensive shock."
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| 2. | Respiratory Paralysis
02/01/1986
- "In contrast, mice and rats given a lethal dose of nimbolide (i.v.) died of a marked and sudden drop in arterial blood pressure and respiratory paralysis within about 1-18 min. Nimbic acid was less toxic to mice with an i.v. LD50 value of 265 mg/kg body wt and i.p"
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| 1. | nimbolide
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