FR 900452

platelet activating factor antagonist from fermentatiion products of Streptomyces phaeofaciens; MF C22-H25-N3-O3-S

Also Known As:

1-methyl-3-(1-(5-methylthiomethyl-6-oxo-3-(2-oxo-3-cyclopenten-1-ylidene)-2-piperazinyl)ethyl)-2-indolinone; FR-900452; WS 7739 B; WS-7739B; WS7739B

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Thrombocytopenia (Thrombopenia) 06/01/1986 - "Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF." 06/01/1986 - "Therefore, in order to determine whether endogenous PAF contributes to the occurrence of thrombocytopenia or leukopenia in endotoxin shock, we assessed the effect of FR-900452 on the thrombocytopenia and the leukopenia following bolus i.v. injection of E.coli endotoxin (0.03 mg/kg) in rabbits. "
2.	Septic Shock (Toxic Shock Syndrome) 06/01/1986 - "Therefore, in order to determine whether endogenous PAF contributes to the occurrence of thrombocytopenia or leukopenia in endotoxin shock, we assessed the effect of FR-900452 on the thrombocytopenia and the leukopenia following bolus i.v. injection of E.coli endotoxin (0.03 mg/kg) in rabbits. "
3.	Proteinuria 08/01/1988 - "[Effect of a specific antagonist of platelet-activating factor, FR-900452, on proteinuria and urinary thromboxane excretion in aminonucleoside nephrotic rats]."
4.	Leukopenia 06/01/1986 - "In contrast, FR-900452 did not reduced the leukopenia at any time of after endotoxin. " 06/01/1986 - "Therefore, in order to determine whether endogenous PAF contributes to the occurrence of thrombocytopenia or leukopenia in endotoxin shock, we assessed the effect of FR-900452 on the thrombocytopenia and the leukopenia following bolus i.v. injection of E.coli endotoxin (0.03 mg/kg) in rabbits. "