RN given refers to all (L)-isomer
Also Known As:
Phe-Arg; phenylalanylarginine, D-Arg-L-Phe; phenylalanylarginine, L-Arg-D-Phe; phenylalanylarginine, all D-isomers
Networked: 18 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results


1. Jiang, Zhi-Dong: 1 article (02/2013)
2. Dupont, Herbert L: 1 article (02/2013)
3. Scherl, Ellen J: 1 article (02/2013)
4. Kothary, Vishesh: 1 article (02/2013)
5. Simpson, Kenneth W: 1 article (02/2013)
6. Dogan, Belgin: 1 article (02/2013)
7. Harel, Josee: 1 article (02/2013)
8. Bosworth, Brian: 1 article (02/2013)
9. Xavier, Catarina: 1 article (03/2008)
10. Correia, João D G: 1 article (03/2008)

Related Diseases

1. Hypokinesia (Bradykinesia)
2. Neoplasms (Cancer)
03/01/2008 - "Taking advantage of the superior biological features associated with the MT-II cyclic peptide, we assessed the effect of lactam-based cyclization on the tumor-seeking properties of alpha-MSH analogs by comparing the pharmacokinetics profile of the 99mTc-labeled cyclic peptide betaAla-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 with that of the linear analog betaAla-Nle-Asp-His-DPhe-Arg-Trp-Lys-NH2 in melanoma-bearing mice. "
12/01/1997 - "Hip-Arg-Phe-, Hip-Phe-Arg- and Hip-His-Leu-cleaving dipeptidyl carboxypeptidase activities were measured in the supernatant (S2) and pellet (P2) fractions obtained by ultracentrifugation of human adrenal tumor preparations. "
12/01/1997 - "Hip-Arg-Phe-, Hip-Phe-Arg- and Hip-His-Leu-cleaving dipeptidyl carboxypeptidases in human adrenal tumors."
09/01/1994 - "Six alpha-MSH(4-10) [Nle-Asp-His-D-Phe-Arg-Trp-Lys-amide] derivatives carrying 2 or 1 or no 2,3-dihydroxy-(2S)-propyl (DHP) groups on the Lys10 amino side chain were coupled to diethylene-triaminopentaacetic acid (DTPA, a chelator for 111In) in monomeric and dimeric forms and tested for their binding activity and bioactivity in vitro with mouse and human melanoma cell lines and by receptor autoradiography to tumor sections, as well as in vivo with normal and melanoma-bearing mice: DTPA-[Nle4,Asp5,D-Phe7,Lys(bis-DHP)10]-alpha-MSH(4-10),DTPA-[Nle4, Asp5, D-Phe7,Lys(mono-DHP)10]-alpha-MSH(4-10), DTPA[Nle4,Asp5,D-Phe7,Lys10]-alpha-MSH(4-10), DTPA-bis-([Nle4,Asp5,D-Phe7,Lys(bis-DHP)10]-alpha-MSH(4-10)), DTPA-bis[([Nle4,Asp5,D-Phe7,Lys(mono-DHP)10]-alpha-MSH(4-10)) and DTPA-bis-([Nle4,Asp5,D-Phe7,Lys10]-alpha-MSH(4-10)). "
11/01/2001 - "In an effort to carry out anti-cancer drug design, we synthesized three new peptide-DMQ-MA conjugates: DMQ-MA-Arg-Arg-Ome, DMQ-MA-Lys(Cbz)-Arg-Ome, DMQ-MA-Lys(Cbz)-Arg-Arg-Ome; two new DMQ-MA-peptide-Chlorambucil (CRB) derivatives: DMQ-MA-Lys(CRB)-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Lys(CRB)-Arg-Ome and four tripeptide-cytotoxic agent conjugates: DMQ-MA-Lys(DMQ-MA)-Phe-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Ile-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Val-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Lys(Cbz)-Arg-Ome. "
3. Amyloid Plaque
4. Pain (Aches)
5. Melanoma (Melanoma, Malignant)

Related Drugs and Biologics

1. arginylarginine (Arg-Arg)
2. alanylglutamate
3. Serotonin (5 Hydroxytryptamine)
4. Potassium Chloride
5. Kallikreins (Kallikrein)
6. Immunoglobulin G (IgG)
7. Bradykinin
8. Amyloid (Amyloid Fibrils)
9. Amino Acids
10. alpha-MSH