|1.||Schally, Andrew V: 44 articles (04/2015 - 06/2002)|
|2.||Block, Norman L: 14 articles (04/2015 - 02/2010)|
|3.||Varga, Jozsef L: 14 articles (02/2012 - 06/2002)|
|4.||Zarandi, Marta: 13 articles (04/2015 - 10/2004)|
|5.||Schally, A V: 10 articles (07/2013 - 09/2000)|
|6.||Rick, Ferenc G: 8 articles (04/2015 - 10/2010)|
|7.||Halmos, Gabor: 7 articles (02/2012 - 06/2002)|
|8.||Szalontay, Luca: 6 articles (04/2015 - 10/2010)|
|9.||Kiaris, Hippokratis: 6 articles (08/2012 - 08/2003)|
|10.||Groot, Kate: 6 articles (07/2005 - 09/2002)|
|1.||Prostatic Neoplasms (Prostate Cancer)
10/01/2014 - "The cross-talk between HER and GHRH-R may be impeded by combining drugs acting upon GHRH receptors and HER family members in human advanced prostate cancer."
07/01/2005 - "Cellular distribution of growth hormone-releasing hormone receptor in human reproductive system and breast and prostate cancers."
03/01/2005 - "In conclusion, GHRH antagonists activate tumoral GHRH receptors and are able to induce apoptosis in LNCaP human prostate cancer cells through a Ca2+-dependent pathway. "
07/07/2005 - "To investigate the role of the GH-IGF-I axis on in vivo prostate carcinogenesis and neoplastic progression, we generated mice genetically predisposed to prostate cancer (the TRAMP model) to be homozygous for lit, a mutation that inactivates the GHRH receptor (GHRH-R) and reduces circulating levels of GH and IGF-I. The lit mutation significantly reduced the percentage of the prostate gland showing neoplastic changes at 35 weeks of age (P=0.0005) and was also associated with improved survival (P<0.01). "
01/21/2014 - "Because growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) are regulated in an autocrine fashion in prostate cancer, inhibition of GHRH-R represents a compelling approach to treatment. "
09/01/2004 - "In vitro and in vivo studies have shown that splice variant 1 (SV1) of the GHRH receptor, which is widely expressed in non-pituitary tissues and cancers, can mediate the proliferative effects of GHRH. "
01/01/2015 - "Synthetic antagonists of the GHRH receptor inhibit proliferation of cancers. "
09/01/2012 - "We conclude that treatment of TNBC with GHRH antagonists reduces tumor growth through an action mediated by tumoral GHRH receptors and produces a suppression of inflammatory cytokine signaling. "
02/01/2010 - "HeLa cervical cancer cells do not express GHRH or GHRH receptors (GHRHRs) and thus do not respond to GHRH or GHRH antagonists. "
07/01/2009 - "Recent evidence demonstrates that splice variants of the GHRH receptor are also expressed in several nonpituitary tissues, both normal and tumoral, as well as in cancer cell lines. "
|3.||Pituitary Neoplasms (Pituitary Adenoma)
08/01/2001 - "Although GHRH receptor variants are common in GH- producing pituitary adenomas, constitutively activating mutations, as a mechanism for GH-producing pituitary tumors appear to be rare."
08/01/2001 - "We hypothesized that activating mutations of the GHRH receptor might occur in a subset of GH-producing pituitary tumors. "
08/01/2001 - "Absence of constitutively activating mutations in the GHRH receptor in GH-producing pituitary tumors."
07/01/1998 - "Inhibition of signal transduction by a splice variant of the growth hormone-releasing hormone receptor expressed in human pituitary adenomas."
06/01/1988 - "In three nonfunctioning pituitary adenomas, GHRH receptors were not detected. "
12/10/2009 - "Linkage analysis with markers spanning 17 known genes for dwarfism revealed linkage of the family to the growth hormone-releasing hormone receptor (GHRHR) gene. "
06/01/2003 - "The recently described syndrome of genetic GHRH receptor deficiency in Pakistan (dwarfism of Sindh) affords a unique opportunity to examine the question of GH deficiency on bone development because the affected patients have congenital, severe, isolated GH deficiency, which had never been treated because of societal reasons. "
06/01/1999 - "Mutations in the growth hormone releasing hormone receptor: a new form of dwarfism in humans."
03/01/1999 - "Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene."
11/01/1998 - "Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh."
|5.||Breast Neoplasms (Breast Cancer)
10/01/2011 - "We detected the presence of pituitary-type GHRH receptors (pGHRH-R) on 6 of the 9 breast cancer cell lines. "
03/27/2007 - "Stimulation of proliferation of MCF-7 breast cancer cells by a transfected splice variant of growth hormone-releasing hormone receptor."
01/01/2003 - "Our results suggest that SVs of GHRH receptors could mediate the responses to GHRH and GHRH antagonists in breast cancer through Ca2+-, cAMP- and PKC-dependent mechanisms. "
06/03/2008 - "In the present study, we demonstrated by western blots the presence of the SV1 of GHRH receptor and the production of GHRH in MDA-MB-468, MDA-MB-435S and T47D human breast cancer cell lines, LNCaP prostate cancer cell line as well as in NCI H838 non-small cell lung carcinoma. "
|1.||Insulin-Like Growth Factor I (IGF-1)
|2.||Growth Hormone-Releasing Hormone (Somatotropin Releasing Hormone)
|3.||Messenger RNA (mRNA)
|5.||Human Growth Hormone (Saizen)
|6.||RNA-Directed DNA Polymerase (Reverse Transcriptase)
|7.||LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)
|8.||Gonadotropin-Releasing Hormone (GnRH)
|9.||somatostatin receptor 2
|1.||Heterologous Transplantation (Xenotransplantation)