|1.||Xia, Qiang: 3 articles (11/2010 - 02/2005)|
|2.||Gao, Qin: 3 articles (11/2010 - 02/2005)|
|3.||Ren, Jian-Dong: 2 articles (07/2014 - 03/2014)|
|4.||Jin, Wei-Hua: 2 articles (07/2014 - 03/2014)|
|5.||Fan, Kai-Hua: 2 articles (07/2014 - 03/2014)|
|6.||Yu, Bo-Tao: 2 articles (07/2014 - 03/2014)|
|7.||Cao, Chun-Mei: 2 articles (12/2005 - 02/2005)|
|8.||Belyaeva, E L: 1 article (07/2015)|
|9.||Hollmann, Markus W: 1 article (01/2015)|
|10.||Berger, Marc M: 1 article (01/2015)|
04/01/2009 - "Twenty-four hours following induction of the initial seizure episode, animals were reinjected with chemoconvulsant in the presence of the BK-channel antagonist paxilline or saline. "
04/01/1999 - "4-AP produced seizure activity similar to the toxins (CD50, 76 ng) whereas paxilline failed to induce seizures at doses up to 13.5 microg. "
07/01/2013 - "In the MES model of seizure, both cannabidiol and paxilline per se produced significant increase in percent protection against electroshock-induced seizure. "
07/01/2013 - "Moreover, while i.c.v. administration of various doses of paxilline did not produce significant change in the PTZ-induced seizure threshold in mice, coadministration of cannabidiol and paxilline attenuated the antiseizure effect of cannabidiol in PTZ-induced tonic seizures. "
04/01/2009 - "Paxilline reduced seizure duration and intensity in pentylenetetrazole-injected animals. "
11/01/2007 - "Hearts from normoxic or hypoxic infant rabbits were perfused with a mitoKCa opener, NS1619, or blocker Paxilline before ischemia and reperfusion. "
01/01/2015 - "The mBKCa channel inhibitor paxilline (1 μM) was administered with and without sildenafil before the onset of ischemia. "
02/01/2005 - "In the isolated perfused rat heart subjected to ischemia/reperfusion, effects of ischemic preconditioning (IPC) on infarct size and lactate dehydrogenase (LDH) release were abolished by 1 microM paxilline (Pax), an inhibitor of the K(Ca) channel, administered 30 min before, but not during, ischemia. "
01/01/2007 - "Infusion of paxilline (1 micromol/L), a blocker of calcium activated potassium channel (K(Ca)) for 10 min before ischemia/reperfusion led to larger infarct size and poorer myocardial performance as compared with the hemin group. "
12/07/2005 - "Pretreatment with 0.2 micromol/L cyclosporin A for the last 5 min of ischemia and first 15 min of reperfusion showed similar effects to those of TNF-alpha, and they were not attenuated by paxilline. "
06/01/1997 - "In contrast, paxilline compounds induce fast-onset and short-duration tremors. "
03/01/1997 - "Paxilline (0.66 to 1.5 mg kg-1) induced mild to moderate tremors immediately which lasted for one to two hours. "
08/01/1990 - "3. The dissolved oxygen concentration in freshly collected sheep bile was in the range 38-163 nmol/ml. 4. Whereas paxilline causes pronounced tremor in the mouse given 4 mg/kg i.p., the dioxygenated paxilline was biologically inactive at ten times this dose. "
12/01/2008 - "To investigate whether the motor function deficits produced by lolitrem B and paxilline are due to inhibition of BK ion channels, their ability to induce tremor and ataxia in mice deficient in this ion channel (Kcnma1(-/-)) was examined. "
12/01/2008 - "Lolitrem B and the structurally related tremor inducer paxilline both act as potent large conductance calcium-activated potassium (BK) channel inhibitors. "
11/01/2007 - "Conversely, neither paxilline nor iberiotoxin inhibited dilation to acute severe or moderate prolonged hypoxia. "
01/01/2012 - "Our data show that paxilline reversed the effects of leptin, both on normoxic and hypoxic neurons, suggesting that the adipokine counteracts hypoxia through BK channels activation in mouse hippocampal neurons."
11/01/2010 - "Pretreatment with Pue at 0.24 mmol/L for 5 min increased the cell viability against hypoxia/reoxygenation injury, while mitochondrial ATP-sensitive potassium channel inhibitor 5-hydroxydecanoate (5-HD, 100 micromol/L, 20 min) or mitochondrial calcium-activated potassium channel blocker paxilline (Pax, 1 micromol/L, 5 min) attenuated the effect of puerarin. "
07/01/2007 - "The main findings are that (1) similar to DADLE (10 microM), H-Dmt-Tic-NH-CH (CH(2)--COOH)-Bid (1-10 microM), a more specific and potent DOR agonist significantly attenuated anoxic K(+) derangement in cortical slice; (2) [D-Ala(2), N-Me-Phe(4), glycinol(5)]-enkephalin (DAGO; 10 microM), a MOR agonist, did not produce any appreciable change in anoxic disruption of K(+) homeostasis; (3) absence of Ca(2+) greatly attenuated anoxic K(+) derangement; (4) inhibition of Ca(2+)-activated K(+) (BK) channels with paxilline (10 microM) reduced anoxic K(+) derangement; (5) DADLE (10 microM) could not further reduce anoxic K(+) derangement in the Ca(2+)-free perfused slices or in the presence of paxilline; and (6) glybenclamide (20 microM), a K(ATP) channel blocker, decreased anoxia-induced K(+) derangement, but DADLE (10 microM) could further attenuate anoxic K(+) derangement in the glybenclamide-perfused slices. "
|5.||Hepatocellular Carcinoma (Hepatoma)
07/01/2015 - "In the present work on rat ascites hepatoma AS-30D cells and isolated rat liver mitochondria we studied action of different BK(Ca) effectors in the absence and presence of Cd2+ in the assay medium, namely of two its openers, N51619 and N5004,and one blocker, paxilline. "
11/01/2009 - "Among them, we found that LXRalpha ligands, i.e., T0901317, paxilline, and 22(R)-hydroxycholesterol, acted potently to induce the expression of ABCC2 at both mRNA and protein levels in human hepatocellular carcinoma HepG2 cells. "
|4.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|5.||Adenosine Triphosphate (ATP)
|7.||Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)
|8.||Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)
|9.||Tetraethylammonium (Tetraethylammonium Bromide)