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paxilline

structure given in first source; RN given refers to (2R-(2alpha,4bbeta,6aalpha,12bbeta,12calpha,14abeta))-isomer
Networked: 30 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Xia, Qiang: 3 articles (11/2010 - 02/2005)
2. Gao, Qin: 3 articles (11/2010 - 02/2005)
3. Ren, Jian-Dong: 2 articles (07/2014 - 03/2014)
4. Jin, Wei-Hua: 2 articles (07/2014 - 03/2014)
5. Fan, Kai-Hua: 2 articles (07/2014 - 03/2014)
6. Yu, Bo-Tao: 2 articles (07/2014 - 03/2014)
7. Cao, Chun-Mei: 2 articles (12/2005 - 02/2005)
8. Belyaeva, E L: 1 article (07/2015)
9. Hollmann, Markus W: 1 article (01/2015)
10. Berger, Marc M: 1 article (01/2015)

Related Diseases

1. Seizures (Seizure)
2. Ischemia
3. Tremor (Tremors)
4. Anoxia (Hypoxia)
11/01/2007 - "Conversely, neither paxilline nor iberiotoxin inhibited dilation to acute severe or moderate prolonged hypoxia. "
01/01/2012 - "Our data show that paxilline reversed the effects of leptin, both on normoxic and hypoxic neurons, suggesting that the adipokine counteracts hypoxia through BK channels activation in mouse hippocampal neurons."
11/01/2010 - "Pretreatment with Pue at 0.24 mmol/L for 5 min increased the cell viability against hypoxia/reoxygenation injury, while mitochondrial ATP-sensitive potassium channel inhibitor 5-hydroxydecanoate (5-HD, 100 micromol/L, 20 min) or mitochondrial calcium-activated potassium channel blocker paxilline (Pax, 1 micromol/L, 5 min) attenuated the effect of puerarin. "
07/01/2007 - "The main findings are that (1) similar to DADLE (10 microM), H-Dmt-Tic-NH-CH (CH(2)--COOH)-Bid (1-10 microM), a more specific and potent DOR agonist significantly attenuated anoxic K(+) derangement in cortical slice; (2) [D-Ala(2), N-Me-Phe(4), glycinol(5)]-enkephalin (DAGO; 10 microM), a MOR agonist, did not produce any appreciable change in anoxic disruption of K(+) homeostasis; (3) absence of Ca(2+) greatly attenuated anoxic K(+) derangement; (4) inhibition of Ca(2+)-activated K(+) (BK) channels with paxilline (10 microM) reduced anoxic K(+) derangement; (5) DADLE (10 microM) could not further reduce anoxic K(+) derangement in the Ca(2+)-free perfused slices or in the presence of paxilline; and (6) glybenclamide (20 microM), a K(ATP) channel blocker, decreased anoxia-induced K(+) derangement, but DADLE (10 microM) could further attenuate anoxic K(+) derangement in the glybenclamide-perfused slices. "
5. Hepatocellular Carcinoma (Hepatoma)

Related Drugs and Biologics

1. Potassium
2. Pentylenetetrazole (Metrazol)
3. Cannabidiol
4. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5. Adenosine Triphosphate (ATP)
6. 5-hydroxydecanoic acid
7. Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)
8. Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)
9. Tetraethylammonium (Tetraethylammonium Bromide)
10. Glyburide (Glibenclamide)

Related Therapies and Procedures

1. Ischemic Postconditioning
2. Intraperitoneal Injections