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2- methyl- 6- phenyl- 3,7- dihydroimidazo(1,2- a)pyrazin- 3- one
Cypridina luciferin analog
Also Known As:
CLA-phenyl; Cypridina luciferin analog; MPDHIP
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrazines: 150
2-methyl-6-phenyl-3,7-dihydroimidazo(1,2-a)pyrazin-3-one: 6
Experts
1.
Masuda, H
: 1 article (01/2001)
2.
Naito, M
: 1 article (01/2001)
3.
Tamai, H
: 1 article (01/2001)
4.
Tanaka, T
: 1 article (01/2001)
5.
Tateishi, M
: 1 article (01/2001)
Related Diseases
1.
Ovarian Neoplasms (Ovarian Cancer)
05/01/1998 - "
The effect of hyperthermia (42 degrees C) on the generation of such active oxygen radicals was examined by chemiluminescence of a Cypridina luciferin analog (CLA) with DNA extracted from a human ovarian cancer cell line (A2780).
"
01/01/2001 - "
Superoxide anions (O2-) generated by cisplatin [cis-diamminedichloroplatinum (II), DDP] were determined by measuring the chemiluminescence from the luminescence probe, 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-3-one (methyl Cypridina luciferin analog, MCLA), in monolayer cultures of a human ovarian cancer cell line (A2780) in physiological saline at pH 7.0.
"
2.
Reperfusion Injury
09/01/1993 - "
A Cypridina luciferin analog (CLA), considered to be a sensitive and specific agent for the assay of superoxide, was assessed in isolated hearts for its effects on ischemia/reperfusion injury.
"
3.
Ventricular Fibrillation
09/01/1993 - "
Cypridina luciferin analog reduces the incidence of ischemia/reperfusion-induced ventricular fibrillation.
"
4.
Liver Diseases (Liver Disease)
08/01/1994 - "
Both Cypridina luciferin analog-dependent chemiluminescence and luminol-dependent chemiluminescence were significantly decreased in neutrophils from patients with chronic liver disease (hepatocellular carcinoma < cirrhosis < chronic active hepatitis) when they were compared with normal healthy subjects.
"
08/01/1994 - "
To evaluate whether neutrophil bactericidal function, the ability to produce oxygen-derived free radicals, is altered in patients with chronic liver disease, we measured chemiluminescence amplified by a luciferin analog (Cypridina luciferin analog-dependent chemiluminescence) and luminol (luminol-dependent chemiluminescence) in response to N-formyl-Met-Lue-Phe by neutrophils from patients with chronic liver diseases due to C and/or B type hepatitis: chronic active hepatitis, cirrhosis and hepatocellular carcinoma.
"
5.
Ischemia
09/01/1993 - "
Cypridina luciferin analog reduces the incidence of ischemia/reperfusion-induced ventricular fibrillation.
"
Related Drugs and Biologics
1.
Superoxides (Superoxide)
2.
Oxygen (Dioxygen)
3.
Luminol
4.
Free Radicals
5.
2- methyl- 6- (4- methoxyphenyl)- 3,7- dihydroimidazo(1,2- alpha)pyrazin- 3- one (MCLA)
6.
Anti-Allergic Agents (Antiallergic Agents)
7.
Reactive Oxygen Species (Oxygen Radicals)
8.
Granulocyte Colony-Stimulating Factor (G-CSF)
9.
Theophylline (Theon)
10.
Peroxidase (Myeloperoxidase)