12/01/1989 - "In 2 of the 5 patients with ventricular tachycardia an evocation of ventricular tachycardias was no more possible after an intravenous application of Bonnecor; a medicamentous termination of the ventricular tachycardias had been tried only in one case. "
12/01/1991 - "The electrophysiologic effects and antiarrhythmic efficacy of tiracizine, a new class I antiarrhythmic drug, were studied in 16 patients with documented sustained ventricular tachycardia (VT) after intravenous drug application and in 6 patients after oral drug administration by means of programmed ventricular stimulation (PVS). "
02/01/1994 - "[The efficacy of bonnecor in refractory ventricular tachycardia in a patient with ischemic heart disease]."
12/01/1991 - "[Electrophysiological anti-arrhythmia effects of tiracizine in ventricular tachycardia]."
12/01/1989 - "For testing the efficiency of Bonnecor in intravenous administration (0.3 mg/kg) 36 patients were examined electrophysiologically (31 with paroxysmal supraventricular tachycardias, 5 with ventricular tachycardias). "
|2.||Cardiac Arrhythmias (Arrythmia)
01/01/1996 - "[The efficacy of anti-arrhythmia therapy with bonnecor in middle-aged and elderly patients]."
06/01/1993 - "[Tiracizine in the treatment of ventricular arrhythmia (preliminary study)]."
12/01/1990 - "[Hemodynamic and clinical studies with Bonnecor--a new anti-arrhythmia drug]."
01/01/1996 - "Antiarrhythmic activity of bonnecor was tried in 15 patients with cardiac arrhythmia. "
01/01/1995 - "The effectiveness of the new antiarrhythmic drug bonnecor was tried in 59 patients with ventricular arrhythmia. "
|3.||Myocardial Ischemia (Ischemic Heart Diseases)
11/01/1992 - "[The effect of bonnecor on blood coagulability and thrombocyte aggregation in transient myocardial ischemia]."
05/01/1990 - "[The effect of bonnecor on cardiac hemodynamics, blood supply and function in experimental myocardial ischemia]."
05/01/1990 - "It was concluded that the relieving influence of bonnecor on the course of acute myocardial ischemia was related to its antifibrillatory and antiarrhythmic properties."
05/01/1990 - "The preventive and therapeutic effects of bonnecor were shown in the experiments on awake and anesthetized rats under conditions of acute myocardial ischemia. "
01/01/1990 - "[Use of bonnecor in ischemic heart disease]."
|4.||Ventricular Premature Complexes (Premature Ventricular Contraction)
01/01/1995 - "Bonnecor effect is dose-dependent: the number of ventricular extrasystoles reduced by 75% in 62 and 74% of the patients receiving 150 mg/day and 20 mg/day, respectively. "
06/01/1993 - "Tiracizine a new antiarrhythmic drug class Ia was tested in a open crossover study in a group of 46 patients with more than 2500 ventricular extrasystoles per 24 hours or with ventricular arrhythmias III or a higher Lown class. "
05/01/1990 - "In 10 patients with frequent ventricular extrasystoles there were studied the antiarrhythmic effectiveness and side effects of a new drug bonnecor at a single intravenous administration in doses from 15 to 60 mg (0.17-0.91 mg/kg). "
12/01/1990 - "Under the influence of verapamil a significant reduction of the ventricular extrasystole could not be verified, the differences between Verapamil and Bonnecor were, however, not to be ascertained statistically. "
08/01/1991 - "The data obtained on 68 patients suffering from cardiac arrhythmia treated with bonnecor or ethacizine demonstrate that bonnecor corrects ventricular extrasystole including high-grade arrhythmia in 80.4% of the patients while ethacizine in 84.6%. "
05/01/1990 - "The clinical pharmacokinetics and the effect of bonnecor on parameters of the pharmacodynamics were studied in 53 patients with cardiac rhythm disorders, including 23 patients in the acute period of myocardial infarction. "
02/01/1990 - "Bonnecor treatment proved effective in arrest of ectopic excitation and is well tolerated by patients with acute myocardial infarction (AMI) and chronic coronary disease (CCD). "
12/01/1990 - "Bonnecor was tested for its antiarrhythmic activity in patients with acute myocardial infarction in the first 24 hours of the disease complicated by arrhythmias as ventricular premature beats (VPB). "
12/01/1990 - "[Anti-arrhythmic effect and kinetic parameters of bonnecor in the treatment of extrasystole in patients with acute myocardial infarction]."
02/01/1990 - "[Effect of Bonnecor on clinical manifestations, bioelectric cardiac activity and cardiac hemodynamics in patients with acute myocardial infarction and chronic ischemic heart disease]."