tiracizine

structure given in first source

Also Known As:

3-carbethoxyamido-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenz(b,f)azepine HCl; 3-carbethoxyamino-5-dimethylaminoacetyl-2,2'-iminodibenzyl HCl; AWD 19166; AWD-19-166; Bonnecor; GS 015; GS 105; GS-015; GS-105; Carbamic acid, (5-((dimethylamino)acetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)-, ethyl ester, monohydrochloride

Networked: 37 relevant articles (7 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Dibenzazepines: 4
      - tiracizine: 37

Related Diseases

1.	Ventricular Tachycardia 12/01/1989 - "In 2 of the 5 patients with ventricular tachycardia an evocation of ventricular tachycardias was no more possible after an intravenous application of Bonnecor; a medicamentous termination of the ventricular tachycardias had been tried only in one case. " 12/01/1989 - "For testing the efficiency of Bonnecor in intravenous administration (0.3 mg/kg) 36 patients were examined electrophysiologically (31 with paroxysmal supraventricular tachycardias, 5 with ventricular tachycardias). " 02/01/1994 - "[The efficacy of bonnecor in refractory ventricular tachycardia in a patient with ischemic heart disease]." 12/01/1991 - "[Electrophysiological anti-arrhythmia effects of tiracizine in ventricular tachycardia]." 12/01/1985 - "The effects of the new antiarrhythmic drug 3-carbethoxy-amino-5-dimethyl-amino-acetyl-iminodibenzyl-hydroc hlorid (Bonnecor) (B.) were investigated by means of clinical-electrophysiologic methods (His-bundle electrography, programmed electrical stimulation) in 11 patients with normal cardiac output and paroxysmal supraventricular tachycardias. "
2.	Cardiac Arrhythmias (Arrythmia) 06/01/1993 - "[Tiracizine in the treatment of ventricular arrhythmia (preliminary study)]." 01/01/1996 - "Antiarrhythmic activity of bonnecor was tried in 15 patients with cardiac arrhythmia. " 01/01/1995 - "[Use of bonnecor in the treatment of ventricular arrhythmia]." 01/01/1993 - "[The pharmacodynamics of the new anti-arrhythmia preparation bonnecor based on the data from an acute drug test]." 05/01/1990 - "[The anti-arrhythmia activity and effect on the heart conduction system of the new anti-arrhythmia preparation bonnecor]."
3.	Myocardial Ischemia (Ischemic Heart Diseases) 11/01/1992 - "[The effect of bonnecor on blood coagulability and thrombocyte aggregation in transient myocardial ischemia]." 01/01/1991 - "[A clinical study of bonnecor in the treatment of heart rhythm disorders in patients with ischemic heart disease]." 05/01/1990 - "[The effect of bonnecor on cardiac hemodynamics, blood supply and function in experimental myocardial ischemia]." 05/01/1990 - "It was concluded that the relieving influence of bonnecor on the course of acute myocardial ischemia was related to its antifibrillatory and antiarrhythmic properties." 01/01/1990 - "[Use of bonnecor in ischemic heart disease]."
4.	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/01/1995 - "Bonnecor effect is dose-dependent: the number of ventricular extrasystoles reduced by 75% in 62 and 74% of the patients receiving 150 mg/day and 20 mg/day, respectively. " 05/01/1990 - "In 10 patients with frequent ventricular extrasystoles there were studied the antiarrhythmic effectiveness and side effects of a new drug bonnecor at a single intravenous administration in doses from 15 to 60 mg (0.17-0.91 mg/kg). " 12/01/1990 - "Under the influence of verapamil a significant reduction of the ventricular extrasystole could not be verified, the differences between Verapamil and Bonnecor were, however, not to be ascertained statistically. " 06/01/1993 - "Tiracizine a new antiarrhythmic drug class Ia was tested in a open crossover study in a group of 46 patients with more than 2500 ventricular extrasystoles per 24 hours or with ventricular arrhythmias III or a higher Lown class. " 08/01/1991 - "The data obtained on 68 patients suffering from cardiac arrhythmia treated with bonnecor or ethacizine demonstrate that bonnecor corrects ventricular extrasystole including high-grade arrhythmia in 80.4% of the patients while ethacizine in 84.6%. "
5.	Myocardial Infarction 05/01/1990 - "The clinical pharmacokinetics and the effect of bonnecor on parameters of the pharmacodynamics were studied in 53 patients with cardiac rhythm disorders, including 23 patients in the acute period of myocardial infarction. " 02/01/1990 - "Bonnecor treatment proved effective in arrest of ectopic excitation and is well tolerated by patients with acute myocardial infarction (AMI) and chronic coronary disease (CCD). " 12/01/1990 - "Bonnecor was tested for its antiarrhythmic activity in patients with acute myocardial infarction in the first 24 hours of the disease complicated by arrhythmias as ventricular premature beats (VPB). " 02/01/1990 - "[Effect of Bonnecor on clinical manifestations, bioelectric cardiac activity and cardiac hemodynamics in patients with acute myocardial infarction and chronic ischemic heart disease]." 05/01/1990 - "The pharmacodynamics, antiarrhythmic activity and tolerance of bonnecor were studied in 25 patients with acute myocardial infarction (AMI) and 23 patients with chronic ischemic heart disease (IHD) complicated by cardiac rhythm disorders in the form of extrasystoles. "

Related Drugs and Biologics

1.	Anti-Arrhythmia Agents
2.	ethacizine
3.	Verapamil (Calan)
4.	Quinidine (Chinidin)
5.	Lidocaine (Xylocaine)
6.	Moricizine (Moracizine)
7.	Procainamide (Procan)
8.	Aconitine
9.	dibenzazepine
10.	tiracizine

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Intravenous Administration
4.	Ligation