Alternaria alternata pathotoxin TA

a hydroxylated long-chain alkylamine with one tricarboxylic acid moiety; inhibits ceramide synthetase; from necrotic leaves of Alternaria infected tomato plants; structure in Toxicon 1993 Mar;31(3):357

Also Known As:

AAL toxin; AAL-TA; pathotoxin TA (Alternaria alternata)

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Sphingosine: 899
      - Alternaria alternata pathotoxin TA: 7
- Alcohols: 595
  - Glycols: 38
    - Sphingosine: 899
      - Alternaria alternata pathotoxin TA: 7
  - Amino Alcohols: 20
    - Sphingosine: 899
      - Alternaria alternata pathotoxin TA: 7

Experts

1.	Fujii, Takayuki: 1 article (08/2012)
2.	Ishihama, Nobuaki: 1 article (08/2012)
3.	Kodama, Motoichiro: 1 article (08/2012)
4.	Mase, Keisuke: 1 article (08/2012)
5.	Mizuno, Takahito: 1 article (08/2012)
6.	Mori, Hitoshi: 1 article (08/2012)
7.	Yoshioka, Hirofumi: 1 article (08/2012)
8.	Archibald, Douglas D: 1 article (04/2007)
9.	Jones, A Daniel: 1 article (04/2007)
10.	Kuldau, Gretchen A: 1 article (04/2007)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 12/01/1995 - "In a search for an analogue of AAL-toxin with high phytotoxicity and low mammalian toxicity, aminopentols [(AP1), hexacetyl AP1 and N-acetyl AP1], and nine analogues (1-9), were tested for toxicity to duckweed (Lemna pausicostata), susceptible tomato (asc/asc) leaf discs, black nightshade leaf discs and mammalian cell lines, including dog kidney (MDCK), rat liver hepatoma (H4TG) and mouse fibroblasts (NIH3T3). " 11/01/1991 - "Approximate IC50 values for the most sensitive hepatoma line, H4TG, were 4, 2 and 10 micrograms/ml for fumonisins B1, B2 and AAL toxin, respectively, in 100 microliters cultures. "
2.	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 01/01/2002 - "The asc,asc genotypes of tomato (Lycopersicon esculentum) and Nicotiana umbratica are sensitive to SAMs and host of the AAL toxin-producing fungus Alternaria alternata f. " 04/01/2007 - "SAMs were quantified using high pressure liquid chromatography (HPLC) with fluorescence detection and high pressure liquid chromatography-mass spectrometry HPLC-MS. The average concentrations and ranges were as follows: fumonisin B(1) 2.02 mug/g (0.20 to 10.10), fumonisin B(2) 0.98 mug/g (0.20 to 20.30), AAL-TA 0.17 mug/g (0.20 to 2.01), and AAL-TB 0.05 mug/g (0.03 to 0.90). "
3.	Wounds and Injuries (Trauma) 08/01/2012 - "VIGS analyses indicated that AAL toxin-triggered cell death (ACD) is dependent upon the mitogen-activated protein (MAP) kinase kinase MEK2, which is upstream of both salicylic acid-induced protein kinase (SIPK) and wound-induced protein kinase (WIPK) responsible for ethylene (ET) synthesis. "
4.	Infections 11/12/2002 - "Transgenic tomato plants bearing the p35 gene were protected against AAL-toxin-induced death and pathogen infection. "
5.	Autolysis 12/01/1998 - "In black nightshade (Solanum nigrum L.) leaf discs floating in solutions of AAL-toxin TA (0.01-200 microM) under continuous light at 25 degrees C, electrolyte leakage, chlorophyll loss, autolysis, and photobleaching were observed within 24 h. "

Related Drugs and Biologics

1.	Fumonisins
2.	Mitogen-Activated Protein Kinase Kinases (MEKs)
3.	Proteins (Proteins, Gene)
4.	Protein Kinases (Protein Kinase)
5.	Mitogens
6.	Electrolytes
7.	Chlorophyll
8.	SA-induced protein kinase
9.	fumonisin B1
10.	ethylene