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cyanopindolol

Networked: 31 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Langhans, Wolfgang: 1 article (01/2003)
2. von Meyenburg, Claudia: 1 article (01/2003)
3. Hrupka, Brian J: 1 article (01/2003)
4. Shea-Donohue, T: 1 article (11/2001)
5. Piñeiro-Carrero, V: 1 article (11/2001)
6. Zhao, A: 1 article (11/2001)
7. Bossone, C: 1 article (11/2001)
8. Bloomquist, W: 1 article (01/2000)
9. Aubert, N: 1 article (01/2000)
10. Lowell, B B: 1 article (01/2000)

Related Diseases

1. Body Weight (Weight, Body)
12/01/1997 - "2. Heart rate was dose-dependently increased by CGP 12177 and cyanopindolol by maximally 150 and 100 beats min(-1), yielding pED50 values of 8.0 and 7.3, respectively (pED50, -log10 of the dose in mol kg(-1) body weight i.v. causing the half-maximum effect), but not affected by the selective beta3-adrenoceptor agonist CL 316243 (pED50 > 6.0). "
02/01/1992 - "1. The long-term effects of sinoaortic denervation on the development of left ventricular hypertrophy (assessed by the measurement of the ratio (R): heart weight/total body weight and LVT: left ventricular thickness), myocardial beta-adrenergic receptivity (measured by [125I]-cyanopindolol binding and adenylate cyclase activity) and plasma catecholamine levels (measured by h.p.l.c.) were investigated in three groups of dogs: normotensive controls (group 1), dogs made hypertensive by sinoaortic denervation and evaluated 1 (group 2) and 18 months (group 3) later. "
02/01/1998 - "3. TG(mREN2)27-rats were characterized by arterial hypertension (TG 194+/-3.2 mmHg vs SD 136+/-2.9 mmHg systolic blood pressure), increased left ventricular weights (TG 4.3+/-0.3 vs SD 3.0+/-0.1 mg g(-1) body weight), decreased myocardial neuropeptide Y (NPY) concentrations (TG 1143+/-108 vs SD 1953+/-134 pg g(-1) wet weight), reduced beta-adrenoceptor densities (TG 51.1+/-1.9 vs SD 63.4+/-3.7 fmol mg[-1]) as assessed by [125I]-cyanopindolol binding studies, and increased Gi(alpha)-activities (TG 4151+/-181 vs SD 3169+/-130 densitometric units) as assessed by pertussis toxin catalyzed [32P]-ADP-ribosylation. "
2. Hypertension (High Blood Pressure)
3. Parkinson Disease (Parkinson's Disease)
4. Neoplasms (Cancer)
5. Lymphoma (Lymphomas)

Related Drugs and Biologics

1. Pertussis Toxin
2. Adenosine Diphosphate (ADP)
3. Neuropeptide Y
4. Adrenergic Receptors (Adrenergic Receptor)
5. beta Adrenergic Receptors
6. Adenylate Cyclase (Adenylyl Cyclase)
7. Serotonin (5 Hydroxytryptamine)
8. Prazosin (Minipress)
9. Ketanserin
10. Isoproterenol (Isoprenaline)

Related Therapies and Procedures

1. Denervation