3-deacetylvecuronium

RN given refers to parent cpd (2beta,3alpha,5alpha,16beta,17beta)-isomer; structure given in first source

Also Known As:

3-deacetylvecuronium bromide, (2beta,3alpha,5alpha,16beta,17beta)-isomer; 3-desacetylvecuronium; 3-hydroxyvecuronium; Org 7268; Org-7268

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Androstanes: 11
      - Androstanols
        Vecuronium Bromide: 639
        3-deacetylvecuronium: 3

Related Diseases

1.	Liver Failure 06/01/1991 - "Also, in cats with liver failure, the duration of action and recovery index of 3-desacetylvecuronium was significantly greater than in control cats (168 +/- 62 vs. 82 +/- 32 min, and 39 +/- 19 vs. 10 +/- 4 min, respectively). "
2.	Renal Insufficiency (Renal Failure) 08/20/1992 - "They also had higher plasma concentrations of 3-desacetylvecuronium and a higher frequency of renal failure (seven of seven patients vs. four of nine patients, P less than 0.03). " 06/01/1991 - "In cats with renal failure, 3-desacetylvecuronium pharmacokinetic and pharmacodynamic variables did not differ from those in control cats. " 08/20/1992 - "Prolonged neuromuscular blockade after the termination of long-term treatment with vecuronium is associated with metabolic acidosis, elevated plasma magnesium concentrations, female sex, and probably more important, the presence of renal failure and high plasma concentrations of 3-desacetylvecuronium."
3.	Paralysis (Palsy) 09/01/1994 - "3-Desacetylvecuronium is a potent neuromuscular blocking drug and may be responsible for episodes of prolonged paralysis after long-term administration of vecuronium to patients in intensive care units."
4.	Acidosis 08/20/1992 - "Prolonged neuromuscular blockade after the termination of long-term treatment with vecuronium is associated with metabolic acidosis, elevated plasma magnesium concentrations, female sex, and probably more important, the presence of renal failure and high plasma concentrations of 3-desacetylvecuronium."

Related Drugs and Biologics

1.	Vecuronium Bromide (Vecuronium)
2.	Magnesium