|1.||Matsuyama, M: 1 article (01/2015)|
|2.||Liner, A: 1 article (01/2015)|
|3.||Ngo, J: 1 article (01/2015)|
|4.||Hoit, B: 1 article (01/2015)|
|5.||Matsuyama, S: 1 article (01/2015)|
|6.||Gerson, S: 1 article (01/2015)|
|7.||Lee, H-G: 1 article (01/2015)|
|8.||Doughman, Y Q: 1 article (01/2015)|
|9.||Hasty, P: 1 article (01/2015)|
|10.||Poventud-Fuentes, I: 1 article (01/2015)|
06/23/1995 - "A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen."
05/09/1995 - "Expression of the 70-kDa polypeptide of human Ku autoantigen in rat cells is shown to suppress specifically the induction of hsp70 upon heat shock. "
07/15/1997 - "Recently, we have shown a constitutive DNA-binding factor in rodent cells that is inactivated by heat shock to be identical to Ku autoantigen. "
08/01/1996 - "In contrast, the promoter-binding activity of enhancer-1-binding factor, a protein related to the Ku autoantigen, which is involved in pol I transcription initiation, was reduced by 50 and 90% after 2 and 3 h of heat shock respectively. "
|2.||Systemic Lupus Erythematosus (Libman-Sacks Disease)
10/01/2001 - "Increased prevalence of autoantibodies to ku antigen in African American versus white patients with systemic lupus erythematosus."
01/01/2000 - "The findings may provide an important link between the established dysregulated function of Ku antigen in auto-immune diseases, such as systemic lupus erythematosus and thyroiditis, and the increasingly recognized 'anti-inflammatory' role of 15-LO-1."
03/25/1989 - "Autoantibodies from a patient with systemic lupus erythematosus were used to isolate cDNA clones encoding the human approximately 70-kDa Ku antigen (p70) from a lambda gt11 expression library. "
06/01/1995 - "The Ku autoantigen is a heterodimer of 70- and 80-kD proteins recognized by autoantibodies from patients with systemic lupus erythematosus and related diseases that is the DNA-binding component of a DNA-dependent protein kinase. "
08/01/2004 - "Several autoantigens including annexin XI-A, the p80 subunit of the Ku antigen, ribosomal protein S6, and other unknown autoantigens could significantly discriminate between breast cancer and non-cancer control sera. "
06/01/2002 - "Several important proteins have been identified from cancer cells as BUR-binding proteins, including poly (ADP-ribose) polymerase (PARP-1), Ku autoantigen, SAF-A, HMG-I(Y), nucleolin and p53. "
12/01/1990 - "Here we show that DNA-PK also phosphorylates the simian virus 40 large tumor antigen, the mouse tumor-suppressor protein p53, the human Ku autoantigen, and two unidentified HeLa DNA-associated polypeptides of 52 and 110 kDa. Identification of these and other newly identified DNA-binding substrates suggest that the dsDNA-activated kinase may regulate transcription, DNA replication, or cell growth."
|4.||Autoimmune Diseases (Autoimmune Disease)
05/01/2002 - "The biochemical properties of this protein resemble that of Ku antigen, a human nuclear DNA-binding heterodimer that is the target of autoimmune-antibodies in several autoimmune diseases. "
05/11/1993 - "The biochemical properties of this negative-acting factor closely resemble those of the Ku antigen, a human nuclear DNA-binding heterodimer which is the target of autoantibodies in several autoimmune diseases. "
08/15/1989 - "The Ku antigen is a DNA-associated nuclear protein recognized by sera from patients with autoimmune diseases. "
09/01/1981 - "Preliminary results of clinical analysis indicated that antibody to the Ku antigen might become a useful marker for a group of patients with clinical characteristics of both polymyositis and scleroderma with a good prognosis."
10/01/1989 - "The ANA spectrum in polymyositis-overlap syndrome was considerably more heterogeneous: patients with polymyositis/progressive systemic scleroderma overlap had antibodies against the nucleolar PM-Scl antigen or the nuclear Ku antigen. "
|1.||DNA (Deoxyribonucleic Acid)
|3.||A-Form DNA (A-DNA)
|4.||Proteins (Proteins, Gene)
|6.||Carrier Proteins (Binding Protein)
|9.||Ribosomal Protein S6
|10.||Interleukin Receptors (Interleukin Receptor)