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Ro 31-0521
suppresses retinoic acid-induced teratogenicity; structure given in first source
Also Known As:
3,3,5,5,-tetraallyl-2-hydroxy-N-(5-methyl-isoxazolyl)-4,6-dioxo-1-cyclohexene-1-carboxamide; Ro-31-0521
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Ketones: 2618
Cyclohexanones: 5
Ro 31-0521: 2
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Alicyclic Hydrocarbons: 1
Cycloparaffins: 6
Cyclohexanes: 3
Cyclohexanones: 5
Ro 31-0521: 2
Related Diseases
1.
Fetal Weight
02/01/1996 - "
Under the conditions here, simultaneous administration of Ro 31-0521 with all-trans-retinoic acid appeared to reduce the total percentage of abnormal fetuses seen after exposure to retinoic acid alone, but fetal body weights remained depressed and the numbers of dead embryos remained elevated, suggesting only limited influence of the cyclohexanetrione on retinoid developmental toxicity.
"
2.
Spinal Dysraphism (Spina Bifida)
01/01/1986 - "
The following retinoic acid-induced malformations were suppressed by Ro 31-0521: malformations of long bones and of apical phalanges induced on days 13 and 15 of gestation, respectively; spina bifida and tail malformations induced on day 11 of gestation and cleft palate induced on day 15 of gestation.
"
3.
Neural Tube Defects (Exencephaly)
01/01/1986 - "
However, cleft palate and other head malformations including exencephaly induced by retinoic acid on day 11 of gestation were not suppressed but even increased by Ro 31-0521.
"
4.
Cleft Palate (Palate, Cleft)
01/01/1986 - "
However, cleft palate and other head malformations including exencephaly induced by retinoic acid on day 11 of gestation were not suppressed but even increased by Ro 31-0521.
"
01/01/1986 - "
The following retinoic acid-induced malformations were suppressed by Ro 31-0521: malformations of long bones and of apical phalanges induced on days 13 and 15 of gestation, respectively; spina bifida and tail malformations induced on day 11 of gestation and cleft palate induced on day 15 of gestation.
"
Related Drugs and Biologics
1.
Tretinoin (Retinoic Acid)
2.
Retinoids