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mulberrofuran G

from Mulberry tree; Diels-Alder type adduct; structure given in first source

Also Known As:

albanol A

Networked: 7 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - mulberrofuran G: 7
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - mulberrofuran G: 7

Experts

1.	Choi, Jae Sue: 2 articles (12/2019 - 11/2018)
2.	Jung, Hyun Ah: 2 articles (12/2019 - 11/2018)
3.	Seong, Su Hui: 2 articles (12/2019 - 11/2018)
4.	Park, Se Eun: 1 article (12/2019)
5.	Paudel, Pradeep: 1 article (12/2019)
6.	Koirala, Prashamsa: 1 article (11/2018)
7.	Shrestha, Srijan: 1 article (11/2018)
8.	Zhou, Yajuan: 1 article (11/2018)
9.	Hong, Sungeun: 1 article (02/2017)
10.	Kim, Dong-Woo: 1 article (02/2017)

Related Diseases

1.	COVID-19 10/07/2022 - "Mulberrofuran G, a Mulberry Component, Prevents SARS-CoV-2 Infection by Blocking the Interaction between SARS-CoV-2 Spike Protein S1 Receptor-Binding Domain and Human Angiotensin-Converting Enzyme 2 Receptor." 10/07/2022 - "In this study, we investigated the inhibitory efficacy of mulberrofuran G (MG), a component of Morus alba L., also known as mulberry, which has been used as food and traditional medicine, on the binding of the spike S1 receptor-binding domain (RBD) protein to the angiotensin-converting enzyme 2 (ACE2) receptor, which is the initial stage of the SARS-CoV-2 infection. "
2.	Parkinson Disease (Parkinson's Disease) 12/10/2019 - "In this study, we delineate the human monoamine oxidase (hMAO) inhibitory potential of natural Diels-Alder type adducts, mulberrofuran G (1), kuwanon G (2), and albanol B (3), from Morus alba root bark to characterize their role in Parkinson's disease (PD) and depression, focusing on their ability to modulate dopaminergic receptors (D1R, D2LR, D3R, and D4R). "
3.	Brain Ischemia (Cerebral Ischemia) 02/01/2017 - "The aim of this study was to investigate the neuroprotective effect of mulberrofuran G (MG) in in vitro and in vivo models of cerebral ischemia. "
4.	Neoplasms (Cancer) 07/01/2007 - "Compounds 1-3, mulberrofuran G, mongolicin C, and chalcomoracin showed moderate cytotoxic activities against five human cancer cell lines, with IC50 values ranging from 4.6-9.2 microg/ml, as determined by MTT assay." 11/01/2018 - "Kuwanon G (KG) and benzofuran flavonoids such as mulberrofuran G (MG) and albanol B (AB) isolated from Morus sp. are reported to exhibit anti-Alzheimer’s disease, anti-inflammatory, fungicidal, anti-cancer, anti-bacterial, and anti-tyrosinase properties. "
5.	Leukemia 04/01/2010 - "Therefore, albanol A may be a promising lead compound for developing an effective drug for treatment of leukemia." 04/01/2010 - "Albanol A (1), isolated from the root bark extract of Morus alba (mulberry), was evaluated for the cytotoxic and apoptosis-inducing activities in human leukemia (HL60) cells, and for the inhibitory activity in human DNA topoisomerases (Topo) I and II. This compound showed potent cytotoxic activity (IC(50) 1.7 microM) on the cells, and potent inhibitory activity on topoisomerase II (IC(50) 22.8 microM). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Angiotensin-Converting Enzyme 2
3.	kuwanon G
4.	albanol B
5.	Neuroprotective Agents
6.	Monoamine Oxidase (MAO)
7.	DNA Topoisomerases
8.	Monophenol Monooxygenase (Tyrosinase)
9.	Sulfur Dioxide
10.	Mucins

Related Therapies and Procedures

1.	Traditional Medicine (Folk Remedies)