SN-07

isolated from Actinomadura roseoviolacea var. miuraensis; effective against lymphocytic leukemia P388; MW 18,000-22,000

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

1.	Leukemia L1210 10/01/1987 - "Mechanisms of action of a novel macromolecular antitumor antibiotic, SN-07, on mouse leukemia L1210 cells in culture." 07/01/1990 - "DNA breaks and repair in mouse leukemia L1210 cells treated with 3 different types of cross-linkers, mitomycin C (MMC), 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitroso ure a hydrochloride (ACNU) and SN-07 (a macromolecular antibiotic), were studied. "
2.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/1989 - "SN-07 also induced chromosomal aberrations and a forward mutation (6-TGr) in Chinese hamster V79 cells after 1 h treatment at 12.5-100 ng/ml without metabolic activation. "
3.	Adenocarcinoma 11/01/2017 - "Among the test compounds, SN-07 (a phenacyl derivative with para phenyl substitution) demonstrated slight cytotoxic effects on two types of human colorectal adenocarcinoma cells HCT-15 and COLO-205. "

1.	Anti-Bacterial Agents (Antibiotics)
2.	Mitomycin (Mitomycin-C)
3.	Nimustine