|1.||Calabrese, Joseph R: 27 articles (12/2014 - 01/2002)|
|2.||Hammer, Anne E: 25 articles (08/2014 - 02/2003)|
|3.||Ketter, Terence A: 22 articles (12/2014 - 02/2002)|
|4.||Bowden, Charles L: 22 articles (08/2013 - 10/2002)|
|5.||Luszczki, Jarogniew J: 20 articles (02/2016 - 01/2004)|
|6.||Vuong, Alain: 18 articles (08/2014 - 02/2003)|
|7.||Messenheimer, John A: 15 articles (08/2014 - 08/2004)|
|8.||Czuczwar, Stanislaw J: 15 articles (11/2013 - 08/2004)|
|9.||Marson, Anthony G: 12 articles (06/2014 - 03/2005)|
|10.||Vieta, Eduard: 12 articles (03/2013 - 08/2003)|
03/01/1996 - "Efficacy measurements were comparable between the three treatment groups, although the higher lamotrigine dose was possibly most effective, with 60.4% completing seizure free compared with 51.3% (LTG 100) and 54.7% (CBZ 600). "
08/01/1990 - "Although there was no significant reduction in total seizure count during the lamotrigine treatment period compared to placebo, there appears to be a drug effect as there was a marked reduction in generalized tonic-clonic seizures in favour of lamotrigine in the last 4 weeks of the treatment period. "
08/01/2008 - "In this study-the first large prospective investigation of the long-term tolerability and efficacy of an antiepileptic drug in a patient population 2 years and younger-lamotrigine administered for up to approximately 72 weeks was well tolerated and associated with good seizure control."
01/01/2001 - "The overall Peto's Odds Ratio (OR) and 95% confidence intervals (CIs) across all studies for 50% or greater reduction in seizure frequency was 2.71 (1.87, 3.91) indicating that lamotrigine is significantly more effective than placebo in reducing seizure frequency. "
01/01/2000 - "The overall Peto's Odds Ratio (OR) and 95% confidence intervals (CIs) across all studies for 50% or greater reduction in seizure frequency was 2.71 (1.87, 3.91) indicating that lamotrigine is significantly more effective than placebo in reducing seizure frequency. "
|2.||Bipolar Disorder (Mania)
10/01/2002 - "Lamotrigine has undergone a remarkable series of systematic studies since 1994 that now establish it as an efficacious, well-tolerated treatment in bipolar disorder. "
05/01/2006 - "The base-case model for patients with a recent manic episode indicated that lamotrigine is the most effective treatment for avoiding both acute depression episodes and all types of acute episodes (depression and mania). "
01/01/2004 - "Lamotrigine is the most widely studied and is effective in treating and preventing bipolar depression, and it is the only anticonvulsant approved by the U.S. "
05/01/2000 - "Lamotrigine has the most evidence in favor of its efficacy, with two double-blind studies in which it was more efficacious than placebo in the treatment of bipolar depression. "
01/01/2014 - "In contrast, lamotrigine, a mood stabilizer, has been proven to be effective in preventing depression in patients with bipolar disorder. "
12/16/2001 - "The new anti-epileptic drugs have a major therapeutic advantage, not only in the management of epilepsy in different clinical situations, but also in the good results observed when using lamotrigine in patients of fertile age."
03/01/1998 - "Lamotrigine (LTG) is a valuable addition to the medical management of epilepsy with wide spectrum of efficacy and good outcomes for quality of life. "
02/01/1998 - "Lamotrigine as add-on treatment (500 mg per day) is effective in patients with refractory epilepsy, but its high cost requires a pharmacoeconomic analysis. "
12/01/2012 - "Overall, lamotrigine is effective and safe in children with refractory epilepsy."
01/01/2000 - "On the other hand, Lamotrigine seems to be more effective in patients with partial epileptic seizures with secondary generalization."
08/01/1998 - "Recent evidence suggests that lamotrigine, which is active at glutaminergic excitatory synapses, is very effective in producing pain relief. "
01/01/2011 - "This updated review adds five new additional studies looking at evidence for Lamotrigine as an effective treatment for acute and chronic pain. "
01/01/2011 - "There is no convincing evidence that lamotrigine is effective in treating acute or chronic pain at doses of about 200-400 mg daily. "
01/23/2001 - "Oral lamotrigine 200 mg daily is a well tolerated and moderately effective treatment for central poststroke pain. "
01/01/2003 - "An open trial was conducted to study the potential efficacy of the antiepileptic agent lamotrigine in relieving the sciatic pain and the relationship between lamotrigine dosage, plasma concentration and the clinical response. "
|5.||Absence Epilepsy (Absence Seizure)
04/27/2004 - "There is also evidence that lamotrigine is effective for newly diagnosed absence seizures in children. "
01/01/2004 - "To investigate to which extent lamotrigine (LTG) may be effective and tolerated as a monotherapy for the treatment of newly diagnosed childhood absence seizures and, secondly, to evaluate the efficacy of this drug on the circadian interictal generalized epileptiform discharges, 20 consecutive newly diagnosed patients (five males, 15 females), aged 3-10 years (mean 6.9 years), affected by childhood absence epilepsy, were administered LTG as first-line drug at the initial dose of 0.5 mg/kg/day for 2 weeks, followed by 1.0 mg/kg/day for an additional 2 weeks. "
07/01/1999 - "To investigate whether lamotrigine (LTG) monotherapy is effective and safe for newly diagnosed typical absence seizures in children and adolescents (aged 3-15 years, n = 45). "
11/01/1997 - "Early data from ambulatory encephalographic (EEG) recordings in patients with previously refractory absence seizures, and from controlled studies on patients with newly diagnosed typical absence seizures, appear to confirm the efficacy of lamotrigine in those patients. "
05/01/2012 - "In this study, we have compared WAG-Rij rats (genetically absence epileptic rats) with Wistar rats, in order to clarify if there is a deficient sensorimotor gating in absence epilepsy, and have examined the effects of lamotrigine (15, 30 mg/kg, i.p.) on this phenomenon. "
|1.||Valproic Acid (Valproate, Semisodium)
|5.||Anticonvulsants (Antiepileptic Drugs)
|8.||Lennox-Gastaut type Epileptic encephalopathy
|1.||Drug Therapy (Chemotherapy)
|2.||Vagus Nerve Stimulation
|4.||Psychology Biofeedback (Biofeedback)